Protein Alignment GlyT and SLC6A3

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 238/589 - (40%)
• Similarity: 352/589 - (59%)
• Gaps: 31/589 - (5%)

  Fly    33 SGTALIQLDATGPGAGGAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLI 97
            :|..|.....|.|.....  ...:|.||..:.|||||::|::|.|.||||||||||.|||||||:
Human    38 NGVQLTSSTLTNPRQSPV--EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLV 100

  Fly    98 PFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTI 162
            |:.:.:||||:||.:|||:.||:...|...|: :.||:.:|:|..:||:|..|..:||:||||.:
Human   101 PYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPILKGVGFTVILISLYVGFFYNVIIAWAL 164

  Fly   163 FYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGAL 227
            .|:|:||...|||.:|..:|::..|......|....::|.       |.|..     ||
Human   165 HYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGL-------NDTFG-----TT------ 211

  Fly   228 KRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFP 290
               ||.|||...||.|  |.||::.|..:..|.|||.|...:::..|.|||::|||||:.||..|
Human   212 ---PAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMP 273

  Fly   291 YVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKF 355
            ||||..|.:||||||||..||..||:.|:.:|..|.||.|||.|:.|:|...:|.||..||||||
Human   274 YVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKF 338

  Fly   356 SNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPV 420
            :||||:|:::....|..|||.:|.|:||.:|::|.:.:|.:..|...|.||.||:|||.:..||:
Human   339 TNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPL 403

  Fly   421 SPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSG 485
            |..|||:||:||||||:||....||:|.|.::|.|..|.:::....|.:.:..::..|...||.|
Human   404 SSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGG 468

  Fly   486 MYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPA 550
            :|...|:|.:||..|:|...:.|.|.:||.||..:|.:|||.|.|:|.   :.:|.:.|:.::|.
Human   469 IYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRP---SLYWRLCWKLVSPC 530

  Fly   551 TLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKH 615
            .|||::..:.|.::|..||.|::|.||:|:||::....:.::.:.|..:....|.  |||:::.:
Human   531 FLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG--SFREKLAY 593

  Fly   616 LLQP 619
            .:.|
Human   594 AIAP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	228/541 (42%)
		Herpes_BLLF1	<884..1135	CDD:282904
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	234/565 (41%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/30 (23%)