DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and SLC6A3

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	589	Identity:	238/589 - (40%)
Similarity:	352/589 - (59%)	Gaps:	31/589 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SGTALIQLDATGPGAGGAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLI 97
            :|..|.....|.|.....  ...:|.||..:.|||||::|::|.|.||||||||||.|||||||:
Human    38 NGVQLTSSTLTNPRQSPV--EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLV 100

  Fly    98 PFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTI 162
            |:.:.:||||:||.:|||:.||:...|...|: :.||:.:|:|..:||:|..|..:||:||||.:
Human   101 PYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPILKGVGFTVILISLYVGFFYNVIIAWAL 164

  Fly   163 FYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGAL 227
            .|:|:||...|||.:|..:|::..|......|....::|.       |.|..     ||
Human   165 HYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGL-------NDTFG-----TT------ 211

  Fly   228 KRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFP 290
               ||.|||...||.|  |.||::.|..:..|.|||.|...:::..|.|||::|||||:.||..|
Human   212 ---PAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMP 273

  Fly   291 YVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKF 355
            ||||..|.:||||||||..||..||:.|:.:|..|.||.|||.|:.|:|...:|.||..||||||
Human   274 YVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKF 338

  Fly   356 SNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPV 420
            :||||:|:::....|..|||.:|.|:||.:|::|.:.:|.:..|...|.||.||:|||.:..||:
Human   339 TNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPL 403

  Fly   421 SPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSG 485
            |..|||:||:||||||:||....||:|.|.::|.|..|.:::....|.:.:..::..|...||.|
Human   404 SSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGG 468

  Fly   486 MYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPA 550
            :|...|:|.:||..|:|...:.|.|.:||.||..:|.:|||.|.|:|.   :.:|.:.|:.::|.
Human   469 IYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRP---SLYWRLCWKLVSPC 530

  Fly   551 TLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKH 615
            .|||::..:.|.::|..||.|::|.||:|:||::....:.::.:.|..:....|.  |||:::.:
Human   531 FLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPG--SFREKLAY 593

  Fly   616 LLQP 619
            .:.|
Human   594 AIAP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	229/547 (42%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	234/565 (41%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820