DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and SLC6A2

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	575	Identity:	244/575 - (42%)
Similarity:	342/575 - (59%)	Gaps:	42/575 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYA 121
            |.||..:.|||||::|::|.|.||||||||||.|||||||||:|:.|:|||:||.:|||:.|||.
Human    56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN 120

  Fly   122 ALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKY 186
            ..|...|: :.||.|:|:|..:||::..|..|||:||||:::|:|:||...|||.:|...|::..
Human   121 REGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPN 184

  Fly   187 CFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGL--SKGIEE 249
            |......:.....|.|.|.:                    .|..||.|::...||.|  |.||.:
Human   185 CTDPKLLNGSVLGNHTKYSK--------------------YKFTPAAEFYERGVLHLHESSGIHD 229

  Fly   250 TGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFY 314
            .|..:..|..||.:...:::..|.|||::|||||:.||..||.||.:|.|.||||||||.||..|
Human   230 IGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294

  Fly   315 LTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGL 379
            |..|:.:|..|.||.|||.||||:|...:|.||..:|||||.||||:|:|:.:..|..|||.:|.
Human   295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGF 359

  Fly   380 VIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALM 444
            .||||:|::|||..|::|.|..:||||.||:|||.::.|..|..|||:||||||.|||||....|
Human   360 AIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGM 424

  Fly   445 ETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISEC 509
            |.|.|.:.|.|..|::::......|....::..|...|..|:|.|.|:|.:||..|:|...:.|.
Human   425 EAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEA 489

  Fly   510 ILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYP 574
            |.::|.||..||.||||.|:|.|.   ..:|.:.|::::||.|||::..:.:.:||..|..|::|
Human   490 IGVSWFYGVDRFSNDIQQMMGFRP---GLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFP 551

  Fly   575 MWADAVGWIVG-----LLPVLVI--FLVAFQEIWRAPMSLSFRDRIKHLLQPTAE 622
            .||:.|||.:.     |:|:.||  ||.....:|         :|:.:.:.|..|
Human   552 PWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLW---------ERLAYGITPENE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	241/554 (44%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	244/575 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820