Protein Alignment GlyT and SLC6A1

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 243/576 - (42%)
• Similarity: 353/576 - (61%)
• Gaps: 51/576 - (8%)

  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            :|.||.||||||:|.:||::||||||||||||..|||||||||:.:.|:.||:||..:|.|.|||
Human    43 DRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQY 107

  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185
            .::|.:.|: :..|:|:|:|....::|..:.:||.:||:|.|:|::.||...|||:.|:..|:|.
Human   108 TSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTD 171

  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEET 250
            .|||            .|.:....|.|||                 ..|::...:..::.|:::.
Human   172 RCFS------------NYSMVNTTNMTSA-----------------VVEFWERNMHQMTDGLDKP 207

  Fly   251 GSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYL 315
            |.|:..||..|.:||.:|:.|:.|||..:||||||:|.:||::|:|||.||||||||..|||||:
Human   208 GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272

  Fly   316 TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLV 380
            ||::::|::::||.|||.||||:.....|.||.|.|||.|.||.|:||:||...|..||.|||.|
Human   273 TPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337

  Fly   381 IFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALME 445
            ||||:||:||.....:..|...|.||||:.|||.||:||:||:||:|||.|||.||:||||..:|
Human   338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVE 402

  Fly   446 TVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAAN-WSVLLIAISE 508
            ...||::|.:|. ||..:...:.:|.|..|:.||...|..|:|..:|.|.|:|: .|:|.:...|
Human   403 GFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   509 CILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVY 573
            |:.|:|.||..||.::||.|:|.|...|   |.:.|.:.||..:..:..|:.|:..|...|:||:
Human   468 CVSISWFYGVNRFYDNIQEMVGSRPCIW---WKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVF 529

  Fly   574 PMWADAVGWIVGLLPVLVI-------FLVAFQEIWRAPMSLSFRDRIKHLLQPTAE 622
            |.|...|||::.|..:::|       ||.         :..|.:.||:.::||:.:
Human   530 PKWGQGVGWLMALSSMVLIPGYMAYMFLT---------LKGSLKQRIQVMVQPSED 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	238/548 (43%)
		Herpes_BLLF1	<884..1135	CDD:282904
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	243/576 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		243/576 (42%)
		PDZ-binding	597..599