DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GlyT and SLC6A1

DIOPT Version :9

Sequence 1:NP_611836.2 Gene:GlyT / 37772 FlyBaseID:FBgn0034911 Length:1188 Species:Drosophila melanogaster
Sequence 2:NP_001335179.1 Gene:SLC6A1 / 6529 HGNCID:11042 Length:599 Species:Homo sapiens


Alignment Length:576 Identity:243/576 - (42%)
Similarity:353/576 - (61%) Gaps:51/576 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            :|.||.||||||:|.:||::||||||||||||..|||||||||:.:.|:.||:||..:|.|.|||
Human    43 DRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQY 107

  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185
            .::|.:.|: :..|:|:|:|....::|..:.:||.:||:|.|:|::.||...|||:.|:..|:|.
Human   108 TSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTD 171

  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEET 250
            .|||            .|.:....|.|||                 ..|::...:..::.|:::.
Human   172 RCFS------------NYSMVNTTNMTSA-----------------VVEFWERNMHQMTDGLDKP 207

  Fly   251 GSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYL 315
            |.|:..||..|.:||.:|:.|:.|||..:||||||:|.:||::|:|||.||||||||..|||||:
Human   208 GQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYI 272

  Fly   316 TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLV 380
            ||::::|::::||.|||.||||:.....|.||.|.|||.|.||.|:||:||...|..||.|||.|
Human   273 TPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFV 337

  Fly   381 IFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALME 445
            ||||:||:||.....:..|...|.||||:.|||.||:||:||:||:|||.|||.||:||||..:|
Human   338 IFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVE 402

  Fly   446 TVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAAN-WSVLLIAISE 508
            ...||::|.:|. ||..:...:.:|.|..|:.||...|..|:|..:|.|.|:|: .|:|.:...|
Human   403 GFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   509 CILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVY 573
            |:.|:|.||..||.::||.|:|.|...|   |.:.|.:.||..:..:..|:.|:..|...|:||:
Human   468 CVSISWFYGVNRFYDNIQEMVGSRPCIW---WKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVF 529

  Fly   574 PMWADAVGWIVGLLPVLVI-------FLVAFQEIWRAPMSLSFRDRIKHLLQPTAE 622
            |.|...|||::.|..:::|       ||.         :..|.:.||:.::||:.:
Human   530 PKWGQGVGWLMALSSMVLIPGYMAYMFLT---------LKGSLKQRIQVMVQPSED 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GlyTNP_611836.2 SNF 57..603 CDD:249680 238/554 (43%)
SLC6A1NP_001335179.1 SLC6sbd_GAT1 2..599 CDD:212075 243/576 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..599 243/576 (42%)
PDZ-binding 597..599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 1 1.000 - - FOG0000575
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.