DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyT and Slc6a17

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001028251.1	Gene:	Slc6a17 / 613226	RGDID:	1587185	Length:	727	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	242/807 - (29%)
Similarity:	361/807 - (44%)	Gaps:	215/807 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LDATGPGAGGAGESEHE-----RGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPF 99
            |:..|...|....:|.|     |..|..:..::|:.:|:||||||:|||||||..|||||:|:|:
  Rat    38 LNVAGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPY 102

  Fly   100 TIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFY 164
            .::|:|.|:||.|:||:.||....|.:.|:...||...|:|....:|...|.||||:||.|::||
  Rat   103 LVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFY 167

  Fly   165 MFASFAPVLPWQNC-----------EPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENN 218
            .|.||...|||..|           ||              :||.::.|.|
  Rat   168 FFKSFQYPLPWSECPVIRNGTVAVVEP--------------ECEKSSATTY-------------- 204

  Fly   219 ITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVV 283
                            ::....|.:|..|.|:|.:...:..||.:||:||.:.:.||:||||||:
  Rat   205 ----------------FWYREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVM 253

  Fly   284 YFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLIT 348
            ||::|||||||....|||:.|.||..|||...||...::.:.|||.:||.|:||||...:||:|.
  Rat   254 YFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIA 318

  Fly   349 LSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELN-----VDVEKVVD------- 401
            .|||||..|||:.|:.:|:|.|..||..|.||:|:::||.|:.:|     .:.||::.
  Rat   319 FSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVL 383

  Fly   402 ----------------------------------------------------QGAGLAFIVYPEV 414
                                                                ||.|||||.:.|.
  Rat   384 SRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEA 448

  Fly   415 VTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLG 479
            :|..|.||.|:|:||:||:.|||.|....|..:||.|:|.|   :..|....:...:|.:..||.
  Rat   449 MTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF---KVPKEMFTVGCCVFAFFVGLL 510

  Fly   480 FTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMW 544
            |...||.|::.:.|.|:|...:.:|.|.|.|.:|||||:::|:.::..|:|.|.:.:.|:   ||
  Rat   511 FVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFY---MW 572

  Fly   545 RYITPATLLFIL-------------FFNWVEYKPAKYGHYVY-PMWADAVGWIVGLLPVLVIFLV 595
            ::::|..:..:.             :..|::.:.|:  .|:| |.||.|          |:|.|:
  Rat   573 KFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAE--RYLYFPNWAMA----------LLITLI 625

  Fly   596 AFQEIWRAPMSLSFRDRIKHLLQPTAEWGPAGRPCVNLHAERYQSQNYDGVTNTKILIEEEASPK 660
            |...:   |:.:.|..|..|||.                         ||.....:..::....|
  Rat   626 AVATL---PIPVVFILRHFHLLS-------------------------DGSNTLSVSYKKGRMMK 662

  Fly   661 QAANKKDRQLTLDVDVDVECLPLATVGKRPG-APKSMGKQGSSGNLQTNAKNGTHKSPTTEISP- 723
            ..:|.::...|..:           :.|.|. ||..|               .||:|   .:.|
  Rat   663 DISNLEENDETRFI-----------LSKVPSEAPSPM---------------PTHRS---YLGPG 698

  Fly   724 SKQPLIPSEKDNKSANIKVLAAGTQSS 750
            |..||..|...|.......|.|.|..|
  Rat   699 STSPLESSSHPNGRYGSGYLLASTPES 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	208/634 (33%)
Slc6a17	NP_001028251.1	SLC6sbd_NTT4	60..648	CDD:271403	215/677 (32%)
Slc6a17	NP_001028251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727		17/64 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820