DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyT and slc6a6b

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	606	Identity:	256/606 - (42%)
Similarity:	360/606 - (59%)	Gaps:	41/606 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PGAGGAGESE--H-ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIA 106
            ||.....|:|  | :|..|..:.|||||:.|..||||||||||||||.|||||||||:.|.|...
Zfish    26 PGTRPEDEAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGG 90

  Fly   107 GLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAP 171
            |||:.|:|::.||:.:.|.:..:.:.||:|.|:|...|::.:::.:||.:|:||.::|:|..|.|
Zfish    91 GLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGYASIVIVSLLNIYYIVILAWGLYYLFQCFQP 155

  Fly   172 VLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYF 236
            .|||.:|...|:|:.|        .|.|     ||  .|.|..|..|.|...      .|..|::
Zfish   156 ELPWASCNNKWNTENC--------VEDT-----LR--RNKTLWAAANATNFT------SPVTEFW 199

  Fly   237 NNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRG 301
            ...||.:|.||||.|.:|..||.||...|.|.|.|:.|||:|:|||||.||.||:|:|::|.|||
Zfish   200 ERNVLSISDGIEEVGHVKWDLALCLLAMWVICFFCVWKGVKSTGKVVYVTATFPFVMLIVLLVRG 264

  Fly   302 VTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIV 366
            ||||||:.||.|||.|:..:|.:.:||.||..||||:.:...|.:.:|.||||:..|||:|.|::
Zfish   265 VTLPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLL 329

  Fly   367 AFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVM 431
            ...|.||||.:|..|||::||:|.|..||:..|.:.|.|||||.||:.||.:|:...||:|||:|
Zfish   330 GGLNSATSFVSGFAIFSVLGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIM 394

  Fly   432 LLTLGLDSQFALMETVTTAILDRFPN-LRQ-YKIWVVLSVAIF-GYIGGLGFTTNSGMYWLQLMD 493
            ||.|||||||..:|...|:::|.:|: ||: |:..:.:::..| .|:.||...|..|||..||.|
Zfish   395 LLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCFVSYLLGLTMVTEGGMYVFQLFD 459

  Fly   494 KYAANWSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILF 557
            .|||:...|| :|..|||.:||:||:..|.:.|:.|||.|...| ..|.  |..:||...:....
Zfish   460 YYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRPNPW-MKWS--WTVVTPFLCVGCFI 521

  Fly   558 FNWVEYKPAKYGH-YVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTA 621
            |:.|:|.|.:|.. |.||.|:..|||.:.|..::.|.:|...:|.::...|.  :|||.:..| .
Zfish   522 FSLVKYAPLRYNKIYEYPDWSIGVGWTLALASMICIPMVVVIKIIQSDGPLI--ERIKAVAAP-V 583

  Fly   622 EWGPAGRPCVNLHAERYQSQN 642
            ..|.:..|      :.||.::
Zfish   584 RGGASSCP------QEYQPKS 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	242/550 (44%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	246/566 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920