Protein Alignment GlyT and slc6a8

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001314797.1
• Gene: slc6a8 / 567544
• ZFINID: ZDB-GENE-071024-2
• Length: 652
• Species: Danio rerio
• Alignment Length: 679
• Identity: 278/679 - (40%)
• Similarity: 384/679 - (56%)
• Gaps: 77/679 - (11%)

  Fly     2 GQSSKSGSA--GVGGVGGGGGVVCPSTAISGCASGTALIQLDATGPGAGGAGESEHERGTWTGRF 64
            |....:|:|  .|.|...||    |.:|.:|..|.....:            |...||.|||.:.
Zfish    23 GHLIPNGNAHPSVNGTLNGG----PMSAATGAISAVEKKR------------EGYPERETWTRQM 71

  Fly    65 DFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVY 129
            ||::|.:|::||||||||||||||.||||.||||:.:.:.:.|:|:.|:|::.||:...|.:.|:
Zfish    72 DFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVW 136

  Fly   130 RRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQAD 194
             ...|||:|||...:::......||.:::||..:|...||...|||..|:..|:|:.|....:..
Zfish   137 -NIAPLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQG 200

  Fly   195 QCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAA 259
            .|:  |||....|..|.|      ...||.|   |.|..|::.|.||.:|.|::|.|::...|..
Zfish   201 DCK--NGTIGNSTFGNLT------CEELANG---RSPIIEFWENKVLNISDGLDEPGAVNWELML 254

  Fly   260 CLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLAN 324
            ||...|.:|:.|:.|||:|:||:|||||.||||||:||.|||||||||..|||:|:.|||.:|..
Zfish   255 CLLAVWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGE 319

  Fly   325 AQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLA 389
            ||||.||..||||:.:...|.|..|.|||:|:|:||||:.::|..|..||||||.|:|||:||:|
Zfish   320 AQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFVVFSILGFMA 384

  Fly   390 HELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDR 454
            .|..||:.||.:.|.|||||.||:.|:.:||:||||.|||:|||.|||||||..:|...|.|||.
Zfish   385 SEQGVDISKVAESGPGLAFIAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFVGVEGFVTGILDL 449

  Fly   455 FPN---LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAISECILIAWI 515
            ||.   :|..:...|....:..:|..|...|..|||..||.|.|:|:...|| .|..||:::||:
Zfish   450 FPGKYYMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWV 514

  Fly   516 YGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH-YVYPMWADA 579
            ||:.||::||..|||.|.:.| ..|  .|..|||...:.|..|:.:.|||..|.: ||||.|.:.
Zfish   515 YGADRFMDDIARMIGYRPFPW-MKW--CWSIITPCVCMGIFLFHLLNYKPLTYNNVYVYPWWGEV 576

  Fly   580 VGWIVGLLPVLVIFLVAFQEIWRAPMSL---------SFRDRIKHLLQPTAEWGPAGRPCVNLHA 635
            :||.:.|..:|.|           |:||         :|::|.::|.:|.  ||        .|.
Zfish   577 IGWCLALSSMLCI-----------PVSLVYKLSGAKGTFKERWENLTKPV--WG--------AHH 620

  Fly   636 ERYQSQNYD---------GVTNTKILIEE 655
            ..|.:.:.|         |:...|::|.|
Zfish   621 LEYMAPDTDIKSLASLSPGMEENKVIIFE 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	249/544 (46%)
		Herpes_BLLF1	<884..1135	CDD:282904
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	265/622 (43%)