DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and Slc6a14

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_038955501.1	Gene:	Slc6a14 / 298340	RGDID:	1561810	Length:	646	Species:	Rattus norvegicus

Alignment Length:	631	Identity:	285/631 - (45%)
Similarity:	395/631 - (62%)	Gaps:	37/631 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFM 113
            |..:...|||.|:.:.|:|||::||:||||||||||||.|.|||||||||:.|||.:|||||.|:
  Rat    34 GENDENQERGNWSKKSDYLLSMVGYAVGLGNVWRFPYLTYTNGGGAFLIPYAIMLALAGLPLFFL 98

  Fly   114 ELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNC 178
            |.|.||:|:||||:|: |..|||:|:|..|:|:|..|.:|||:|||::::|:||||..||||.||
  Rat    99 ECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYLFASFQSVLPWANC 162

  Fly   179 EPAWSTKYCFSYAQADQCEA---TNGTYYLRTCHNATSAAENNITTLALGALKRP---PAEEYFN 237
            ..:|:...|........|..   |.|..::    |.:....||.|.|....:.||   |:|:|::
  Rat   163 SSSWADDNCSRQPIVTGCRVSTDTGGDMFM----NISWVNSNNFTCLNGSEVFRPGQLPSEQYWD 223

  Fly   238 NFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGV 302
            ...|..|.|::|||.|...||.||.|||.||...|.||::|||||||||||||||||:||.:||.
  Rat   224 KVTLRRSSGMDETGVIVWYLALCLLLAWIIVGAALFKGIKSSGKVVYFTALFPYVVLLILLIRGA 288

  Fly   303 TLPGASTGILFYL--TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLI 365
            ||.|||.||.:|:  ..::.:|..|:||.|||.|||::||.|||||:.|||||||:||||.|::|
  Rat   289 TLEGASKGISYYIGAQSNFTKLREAEVWKDAATQIFYSLSVAWGGLVALSSYNKFNNNCYSDAII 353

  Fly   366 VAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFV 430
            |...|..||.|||..||||:|.:||....:|.:||..|..||||.|||.:.:||..|.|::|||.
  Rat   354 VCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFF 418

  Fly   431 MLLTLGLDSQFALMETVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDK 494
            ||||||||||||.:||:||.|.|.||. :::.::.:.|...:..::.||...|.:|:||:.|:|.
  Rat   419 MLLTLGLDSQFASIETITTTIQDLFPKAMKRMRVPITLGCCLILFLLGLVCVTQAGIYWVHLIDH 483

  Fly   495 YAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFN 559
            :.|.|.:|:.||.|...|.||||..||:.||:.|||.:.|.:..:|...|..|||..|..||.::
  Rat   484 FCAGWGILIAAILEIAGIIWIYGGNRFIEDIEMMIGAKRWLFWLWWRACWFVITPILLSAILVWS 548

  Fly   560 WVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWG 624
            .|::....|....||.|..|:||.:.:..::.|.::|..:|.||..::  ..||....:|.:.||
  Rat   549 LVKFHRPNYADIPYPDWGVALGWCMIIFCIIWIPIMAIIKIVRAEGNI--LQRIIKCCRPASNWG 611

  Fly   625 PAGRPCVNLHAERYQSQNYDGVTNTKILIEEEASPKQAANKKDRQL 670
            |        :.|:::.:.|          ::.|.|   |.:.|.::
  Rat   612 P--------YLEKHRGERY----------KDMAEP---AKETDHEI 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	269/554 (49%)
Slc6a14	XP_038955501.1	SLC6sbd_ATB0	42..645	CDD:271391	283/623 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1106
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm63542
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.730