Protein Alignment GlyT and Slc6a4

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 607
• Identity: 239/607 - (39%)
• Similarity: 360/607 - (59%)
• Gaps: 56/607 - (9%)

  Fly    45 PGAGGAGESEH----------------ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGG 93
            |......|:.|                ||.||..:.|||||::||:|.|||:|||||:||.||||
  Rat    51 PSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGG 115

  Fly    94 AFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLII 158
            |||:|:|||.:..|:||.:|||:.|||...|.::::|:.||:|:|:|..:.:::..:..|||.||
  Rat   116 AFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII 180

  Fly   159 AWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLA 223
            ||.::|:.:|....|||.:|..:|:|..|.:|...|     |.|:   |.|:.:
  Rat   181 AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQD-----NITW---TLHSTS----------- 226

  Fly   224 LGALKRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFT 286
                   ||||::...||.:  |||:::.|:|...|..|:.|.:|:::..:.|||::|||||:.|
  Rat   227 -------PAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVT 284

  Fly   287 ALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSS 351
            |.|||:||.:|.|||.|||||..|::|||.|:|::|....||.|||.||||:|.|.:|.|:..:|
  Rat   285 ATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFAS 349

  Fly   352 YNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVV-DQGAGLAFIVYPEVV 415
            ||||:||||:|:|:.:..|..|||.:|.|||:::|::|...|.||.:|. |.|..|.||.|.|.:
  Rat   350 YNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAI 414

  Fly   416 TRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPNL-RQYKIWVVLSVAIFGYIGGLG 479
            ..:|.|..:|::||:||:||||||.||.:|.|.||:||.||:: .:.:.|.||.|.|...:|.|.
  Rat   415 ANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLL 479

  Fly   480 FTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIG-KRSWFWNFFWGIM 543
            ..|:.|.|.:.|:::||...:||.:|:.|.:.::|.||..:|.:|::.|:| ...|||.    |.
  Rat   480 TLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWR----IC 540

  Fly   544 WRYITPATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLS 608
            |..|:|..||||:....:.....:...|.||.|:..:|:.:|:..|:.|.......:...|.:|
  Rat   541 WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTL- 604

  Fly   609 FRDRIKHLLQPTAEWGPAGRPC 630
             ::||...:.|..   |...||
  Rat   605 -KERIIKSITPET---PTEIPC 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	227/544 (42%)
		Herpes_BLLF1	<884..1135	CDD:282904
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60		2/8 (25%)
		5HT_transport_N	24..64	CDD:397524	3/12 (25%)
		SLC6sbd_SERT	79..615	CDD:271399	231/567 (41%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		3/10 (30%)