Protein Alignment GlyT and Slc6a3

DIOPT Version :9

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 235/567 - (41%)
• Similarity: 346/567 - (61%)
• Gaps: 32/567 - (5%)

  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            ||.||:.:.|||||::|::|.|.||||||||||.|||||||:|:.:.:||||:||.:|||:.||:
  Rat    59 ERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQF 123

  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185
            ...|...|: :.||:.:|:|..:||:|..|..:||:||||.:.|.|:||...|||.:|...|::.
  Rat   124 NREGAAGVW-KICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSP 187

  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALG-ALKRPPAEEYFNNFVLGL--SKGI 247
            .|                       :.:.|.|:...|.|. .....||.|||...||.|  |:||
  Rat   188 NC-----------------------SDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGI 229

  Fly   248 EETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGIL 312
            ::.|..:..|.|||.|...:::..|.|||::|||||:.||..|||||..|.:||||||||..||.
  Rat   230 DDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIR 294

  Fly   313 FYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFA 377
            .||:.|:.:|..|.||.|||.|:.|:|...:|.||..||||||:||||:|::|....|..|||.:
  Rat   295 AYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSS 359

  Fly   378 GLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFA 442
            |.|:||.:|::|.:.||.:..|...|.||.||:|||.:..||:|..||.:||:||||||:||...
  Rat   360 GFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMG 424

  Fly   443 LMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAIS 507
            .||:|.|.::|.|..|.:::....|.:.:..::..|...||.|:|...|:|.:||..|:|...:.
  Rat   425 GMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLI 489

  Fly   508 ECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYV 572
            |.|.:||.||.|:|.:||:.|.|:|.   |.:|.:.|:.::|..||:::..:.|.::|..||.|:
  Rat   490 EAIGVAWFYGVQQFSDDIKQMTGQRP---NLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYI 551

  Fly   573 YPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQP 619
            :|.||:|:|||:....:.::.:.|..:....|.  |||:::.:.:.|
  Rat   552 FPDWANALGWIIATSSMAMVPIYATYKFCSLPG--SFREKLAYAITP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	229/548 (42%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	234/566 (41%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		8/30 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820