DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and snf-12

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_509527.1	Gene:	snf-12 / 181143	WormBaseID:	WBGene00004911	Length:	1022	Species:	Caenorhabditis elegans

Alignment Length:	877	Identity:	231/877 - (26%)
Similarity:	381/877 - (43%)	Gaps:	176/877 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYA 121
            |..|..:.||.||.||:.||:|:..|||...|.:|||.|.||:...|:..||||:|:.||.|||.
Worm   157 RELWRTQKDFFLSCLGFMVGVGHTMRFPAKVYQHGGGVFFIPYLFSLIFFGLPLVFLHLSLGQYT 221

  Fly   122 ALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFAS-----FAPVLPWQNCEPA 181
            .......::|..|:..|:|..:::::..|.:|||:|:||.|.|.|.|     ....|||:.|...
Worm   222 GQAANTAFQRLMPIGSGVGWALVVIAIPVAVYYNIIVAWAIHYFFQSAKGLLLGDELPWETCRDE 286

  Fly   182 WSTKYCFSYAQADQ--CEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLS 244
            |         |.|.  |...|    |.:|.|:|    |:||.          .|.:|::.||.||
Worm   287 W---------QLDNRCCNLHN----LHSCFNST----NSITA----------PEAFFHSEVLSLS 324

  Fly   245 K-GIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGAS 308
            . |....|.::..|...|..||.:||..:.||:.|..:.:..||..||::|.||.:||::||||:
Worm   325 TFGDFALGPLQSHLVLSLAAAWLLVFFGVFKGLGSIAQTMNVTATVPYLLLSILLLRGISLPGAN 389

  Fly   309 TGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIAT 373
            .|:.|..|.|..:|...|:|..||.|:|:.|....|.||::::::::.||.|:||:::...:..|
Worm   390 KGLTFLFTVDSTKLWKWQIWKSAAEQVFYELGIDAGPLISMAAFSRYRNNIYRDSVLLVIMDALT 454

  Fly   374 SFFAGLVIFSIIGFLAHELNVDVEKVVDQG-AGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGL 437
            |..:|:||||.:||:|.|.|.:|..|:... ..|:|.|||.|.:.:....:||.|||.||:...:
Worm   455 SCLSGMVIFSFVGFIASESNSNVNDVLKHDPLYLSFTVYPGVTSFMYWGGLWATLFFGMLVLAAI 519

  Fly   438 DSQFALMETVTTAILDRFP---NLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANW 499
            |::||.:|.:.:|.::.|.   ...:.::...|.:|  |:..||......|::....::...|||
Worm   520 DAEFAWLEMIASAFMNHFSMKNKAVENRLLAFLCLA--GFFLGLPLCAQGGIFVFHAIENLNANW 582

  Fly   500 SVLLIAISECILIAWIYGSQRFLNDIQGM-------IGKRSWFWN---FFWG-------IMWRYI 547
            :...:|:....::.::||...:|.||..|       |.|.:....   :|:|       ....:|
Worm   583 NSFSLALLSVAIVCYVYGIDNYLTDISAMLRVPRIQISKATRLKEKLIYFFGPGGIYIKFSLCFI 647

  Fly   548 TPATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEI------------ 600
            .|..|..:|..:.:.|:...:.....|:..:.|.|||.:.|:||:.||||.:|
Worm   648 CPVILTVLLVASVLGYQRISFAGRPIPIDYEIVAWIVMIGPLLVVPLVAFMQIRQIRNEGKLLKS 712

  Fly   601 ------WRAPMSLSFRDRIKHLLQPTAEWGPAGR---PCVNLHAER-YQSQNYDGVT-NTKIL-- 652
                  ||.....|...:..::.|......|..|   |.:..|.|. |...:..|.| .:::.
Worm   713 LFDTSEWRESQDDSLEPKDLYMRQSGKFESPPNRRRTPTIFTHRENTYMYIDSRGPTVRSRVFPL 777

  Fly   653 --------------------IEEEAS--------------PKQAANKKDRQLTL----------- 672
                                |||.||              .....:..|.:|||
Worm   778 GASLDPYGWKAGRLRDRQQQIEETASNYSEEDSATTNSFMASTVKHNDDMELTLFGSPPAILGDD 842

  Fly   673 ----------DVDVDVECLPLATVGKRPGAPKSMGKQGSSGNLQTNAKNGTHKS-----PTTEIS 722
                      .:.|:.:|..:..    |..|..:.:.......:|..|..:..:     ||:.:.
Worm   843 EKIMTTRFSESMPVNYKCRNVEV----PRIPNKLPQNMERMARKTRKKRSSPSASDPPVPTSPLP 903

  Fly   723 P--------SKQPLIPSEKDNKSANIKVLAAGTQS---------SGRECTTMSTFAGGGEKKS-- 768
            |        |:.|::.|:   :|.:.:::..|..|         |..:|...:|..   .:|:
Worm   904 PPPKLQHCRSEPPMMNSK---ESHSPEIITPGDDSPSISNSSDDSSDDCFRRATVI---RRKTSD 962

  Fly   769 ----TKVNLATGATSAAAPLASSNIATAATVA 796
                |..:.||..:.:..||......:.::||
Worm   963 DDAFTHFSTATAESISITPLDFPRQRSLSSVA 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	185/592 (31%)
snf-12	NP_509527.1	SLC6sbd	158..660	CDD:271359	169/530 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820