DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and Slc6a13

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006237280.2	Gene:	Slc6a13 / 171163	RGDID:	620788	Length:	608	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	244/598 - (40%)
Similarity:	351/598 - (58%)	Gaps:	66/598 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            ||..||.:.:|:||:.|..:|||||||||||||.||||||.||:.|.|...|:|:.|:|.:.|||
  Rat    31 EREQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQY 95

  Fly   121 AALGPVAVYRRFCPLFR------GLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCE 179
            ...|.:..:|:.||:|.      |:|....::.:::.:||.:::||.:||:|:||...|||.:|.
  Rat    96 TNQGGITAWRKICPIFEASVPSPGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCS 160

  Fly   180 PAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLS 244
            ..|:|:.|..:      :.||.:..: |..||||                 |..|::...||.:|
  Rat   161 HEWNTENCVEF------QKTNNSLNV-TSENATS-----------------PVIEFWERRVLKIS 201

  Fly   245 KGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGAST 309
            .||:..||::..|..||.|||.|.:.|:.|||:|:||||||||.|||::||:|.:||||||||:.
  Rat   202 DGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQ 266

  Fly   310 GILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATS 374
            ||.|||.|:..:|.:.|||.||..||||:.:...|.|..|.||||:.||||:|.:.:...|.:||
  Rat   267 GIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCVALCILNSSTS 331

  Fly   375 FFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDS 439
            |.||..||||:||::.|..|.:.:|.:.|.|||||.||..|..||.||:||..||.|::.|||||
  Rat   332 FVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDS 396

  Fly   440 QFALMETVTTAILDRFP------NLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAAN 498
            ||..:|::.||::|.:|      |.|:.   ::|.|::..:..||...|..|||..||.|.|||:
  Rat   397 QFVCVESLVTALVDMYPRVFRKKNRREI---LILIVSVVSFFIGLIMLTEGGMYVFQLFDYYAAS 458

  Fly   499 WSVLL-IAISECILIAWIYGSQRFLNDIQGMIGKRSW-----FWNFFWGIMWRYITPATLLFILF 557
            ...|| :||.|.:.:||:||:.||.::|:.|||.:.|     .|.||        |||..|....
  Rat   459 GMCLLFVAIFESLCVAWVYGASRFYDNIEDMIGYKPWPLIKYCWLFF--------TPAVCLATFL 515

  Fly   558 FNWVEYKPAKYG-HYVYPMWADAVGWIVGL-----LPVLVIFLVAFQEIWRAPMSLSFRDRIKHL 616
            |:.::|.|..|. .|.||.|.||:||::.|     :|...|:.:   ...:.|:    |:|::.|
  Rat   516 FSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSIYKL---RTLKGPL----RERLRQL 573

  Fly   617 LQPTAEWGPAGRP 629
            :.|..:.....:|
  Rat   574 VCPAEDLPQKSQP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	237/569 (42%)
Slc6a13	XP_006237280.2	SLC5-6-like_sbd	32..581	CDD:382020	242/590 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820