DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlyT and Slc6a12

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus

Alignment Length:	587	Identity:	245/587 - (41%)
Similarity:	358/587 - (60%)	Gaps:	51/587 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            :||.||.:.:|:||:.|..:|||||||||||||.||||||.||:.|.....|:|:.|:|::.|||
Mouse    49 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQY 113

  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185
            ::.|.|..:|:.|||.:|:|...:::.:.:.:||.:|:||.:||:|:||...|||..|..:|:|:
Mouse   114 SSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTE 178

  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEET 250
            :|..:.........:.:      .|.||                 |..|::...|||::.||.:.
Mouse   179 HCVDFLNHSSARGVSSS------ENFTS-----------------PVMEFWERRVLGITSGIHDL 220

  Fly   251 GSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYL 315
            ||::..||.||.|||.|.:.|:.|||:|:||||||||.|||::|:||.:||||||||..||:|||
Mouse   221 GSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYL 285

  Fly   316 TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLV 380
            .||..:|.:.|||.||..||||:.:...|.|..|.||||:.||||:||:.:.|.|.||||.||.|
Mouse   286 KPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFV 350

  Fly   381 IFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALME 445
            :|||:||::.|..:.:.:|.:.|.|||||.:|:.||.:|:|.:|:.|||:|||.|||||||..||
Mouse   351 VFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCME 415

  Fly   446 TVTTAILDRFP-NLRQ--YKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLL-IAI 506
            .:.||.:|.|| .||:  .:..::|::::..|:.||...|..|||..||.|.||::...|| :::
Mouse   416 CLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSL 480

  Fly   507 SECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH- 570
            .|.|.|.|:||:.||.::::.|||.|.|   ....|.|.::||...|...||:..:|.|.||.:
Mouse   481 FEVICIGWVYGADRFYDNVEDMIGYRPW---PLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNV 542

  Fly   571 YVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSL---------SFRDRIKHLLQPTAEWGPA 626
            |:||.|..::||           |:||..:...|:.:         ||:.|::.|:.|.......
Mouse   543 YMYPSWGYSIGW-----------LLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQP 596

  Fly   627 GR 628
            ||
Mouse   597 GR 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	237/550 (43%)
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	242/576 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820