DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyT and Slc6a7

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	276/627 - (44%)
Similarity:	401/627 - (63%)	Gaps:	51/627 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQY 120
            :||.|||:.|||||.:||.|||||||||||..|.|||||||:|:.:||.|.|:||.|:|||.||:
  Rat    36 DRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQF 100

  Fly   121 AALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTK 185
            ::|||:||: :..|||:|.|..|:|:..:|.:|||:|||:.:||:|||....|||::|...|:|:
  Rat   101 SSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSNLPWEHCGNWWNTE 164

  Fly   186 YCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGL--SKGIE 248
            .|..:               |...:...|...|:::..      .|:|||::.:||.:  |:||.
  Rat   165 RCLEH---------------RGPKDGNGALPLNLSSTV------SPSEEYWSRYVLHIQGSQGIG 208

  Fly   249 ETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILF 313
            ..|.|:.:|..||.|||.|||||:.|||:||||||||||.|||::|::|.|||||||||..||.|
  Rat   209 RPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQF 273

  Fly   314 YLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAG 378
            ||||.:..|.:::||.:||:|||::|...:|||:|.:|||.|..|.|:|:.||...|..||..||
  Rat   274 YLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAG 338

  Fly   379 LVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFAL 443
            ..|||::|:::.||.|.|::|...|.||||:|||:.:|.||:||.|:.|||.||||||||||||.
  Rat   339 FAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAF 403

  Fly   444 METVTTAILDRFP-NLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAIS 507
            :||:.||:.|.|| .||..|......:.:..|:.||..||:.|||||.|:|.|:|::.::::.|:
  Rat   404 LETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVIT 468

  Fly   508 ECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYV 572
            .|:.:..:||.|||..||..|:|.:.   ..::...|.:::|||||.:|.::.|:|:|::||.|.
  Rat   469 TCLAVTRVYGIQRFCRDIHMMLGFKP---GLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYR 530

  Fly   573 YPMWADAVGWIVGLLPVLVI---FLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPA------GR 628
            :|.||:.:|.::|||..|:|   .|||   :.|...||  .:|::...:|..:|||:      |.
  Rat   531 FPAWAELLGILMGLLSCLMIPAGMLVA---VLREEGSL--WERLQQASRPAIDWGPSLEENRTGM 590

  Fly   629 PCVNLHAER------YQSQNYDGVT---NTKILIEEEASPKQ 661
            ....|...:      ...:.|.|:|   ||.|.::.|.:.::
  Rat   591 YVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEE 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	259/551 (47%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	265/573 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720