Protein Alignment GlyT and SLC6A14

DIOPT Version :9

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 279/626 - (44%)
• Similarity: 396/626 - (63%)
• Gaps: 21/626 - (3%)

  Fly    49 GAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFM 113
            |..:...:||.|:.:.|:|||::||:||||||||||||.|:|||||||||:.|||.:|||||.|:
Human    28 GENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFL 92

  Fly   114 ELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNC 178
            |.|.||:|:||||:|: |..|||:|:|..|:|:|..|.:|||:|||::::||||||...|||:||
Human    93 ECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNC 156

  Fly   179 EPAWSTKYCFSYAQADQCEATNGTYYLRTC--HNATSAAENNITTLALGALKRP---PAEEYFNN 238
            . :||.|.|........|..:.....::..  .|.:....||.|.:....:.:|   |:|:|:|.
Human   157 S-SWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNK 220

  Fly   239 FVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVT 303
            ..|..|.|:.|||.|...||.||.|||.||...|.||::|||||||||||||||||:||.|||.|
Human   221 VALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGAT 285

  Fly   304 LPGASTGILFYL--TPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIV 366
            |.|||.||.:|:  ..::.:|..|:||.|||.|||::||.|||||:.|||||||.|||:.|:::|
Human   286 LEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVV 350

  Fly   367 AFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVM 431
            ...|..||.|||..||||:|.:||....:|.:||..|..||||.|||.:.:||..|.|::|||.|
Human   351 CLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFM 415

  Fly   432 LLTLGLDSQFALMETVTTAILDRFPN-LRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKY 495
            |||||||||||.:||:||.|.|.||. :::.::.:.|...:..::.||...|.:|:||:.|:|.:
Human   416 LLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF 480

  Fly   496 AANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNW 560
            .|.|.:|:.||.|.:.|.||||..||:.|.:.|||.:.|.:..:|...|..|||..|:.|..::.
Human   481 CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSL 545

  Fly   561 VEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGP 625
            |::....||...||.|..|:||.:.:..::.|.::|..:|.:|..::.  .|:....:|.:.|||
Human   546 VQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIF--QRLISCCRPASNWGP 608

  Fly   626 AGRPCVNLHAERYQSQNYDGVTNTKILIEEEASPKQAANKK 666
                    :.|:::.:.|..:.:.|...:.|. |..:.::|
Human   609 --------YLEQHRGERYKDMVDPKKEADHEI-PTVSGSRK 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	266/553 (48%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	278/618 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642		4/20 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1183
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42299
orthoMCL	1	0.900	-	-		OOG6_100873
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770