Protein Alignment GlyT and Slc6a5

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_006540608.1
• Gene: Slc6a5 / 104245
• MGIID: 105090
• Length: 831
• Species: Mus musculus
• Alignment Length: 689
• Identity: 309/689 - (44%)
• Similarity: 429/689 - (62%)
• Gaps: 66/689 - (9%)

  Fly     2 GQSSK----SGSAGVG-----------------GVGGGGGVV----CPSTAISGCASGTALIQLD 41
            |.|::    ||.||.|                 .|..|.|.:    .|:......:..|.::..|
Mouse   134 GHSAQANPPSGPAGAGNALHCKIPALRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTD 198

  Fly    42 ATG---PGAGGA--------GESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAF 95
            ...   ||:...        |:....||.|:.:.||:||::||:||||||||||||.:.||||||
Mouse   199 GIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAF 263

  Fly    96 LIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAW 160
            |||:.:||.:||||:.|:|:|.||:|:.|||:|::.. |..:|.|..|:::|.::.:|||:||.:
Mouse   264 LIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICY 327

  Fly   161 TIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQ--ADQC--------EATNGTYYLRTCHNATS-- 213
            |:||:||||..||||.:|...|:|..|....:  .|.|        :..|.|:.:....|.|.
Mouse   328 TLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVN 392

  Fly   214 -AAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQ 277
             .::.|.|.::       .:||||..|||.:|.|||..|.|:..||.||||||.||:..|.||::
Mouse   393 FTSQTNKTFVS-------GSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIK 450

  Fly   278 SSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPA 342
            ||||||||||.|||||||||.:||||||||..||.:::||.|::|.:|.||.|||.||||:||.|
Mouse   451 SSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAA 515

  Fly   343 WGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLA 407
            |||||||||||||.||||:|:|||...|.|||.|||.||||:|||:|:|..|::|.|.|||.|:|
Mouse   516 WGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIA 580

  Fly   408 FIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRFPN-LRQYKIWVVLSVAI 471
            |:||||.:||||:||.||::||:||||||||:.||.:||:.|:|.|.||. ||.:|....|...|
Mouse   581 FVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCI 645

  Fly   472 FGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFW 536
            ..:|.|....|..|:|..||:|.|||::::::|||.|.:.|:::||.|||..||:.|||.:.
Mouse   646 CFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKP--- 707

  Fly   537 NFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPMWADAVGWIVGLLPVLVIFLVAFQEIW 601
            |.||.:.|.::||..|.|||.|::.:::|..||.|.||.|:..:||::....|:.|.::...:::
Mouse   708 NIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMY 772

  Fly   602 RAPMSLSFRDRIKHLLQPTAEWGPAGRPCVNLHAERYQS 640
            .||.  .|.:|:|.:..|..:|||.   ......|||::
Mouse   773 LAPG--RFIERLKLVCSPQPDWGPF---LAQHRGERYKN 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	281/553 (51%)
		Herpes_BLLF1	<884..1135	CDD:282904
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	293/598 (49%)