DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyT and Slc6a15

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001239259.1	Gene:	Slc6a15 / 103098	MGIID:	2143484	Length:	729	Species:	Mus musculus

Alignment Length:	757	Identity:	231/757 - (30%)
Similarity:	353/757 - (46%)	Gaps:	177/757 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 AGGAGESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLM 111
            |....|::.||..|..:..::|:.:|:||||||||||||||..|||||:|:|:.|:|::.|:||.
Mouse    51 AEDGSEADDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLF 115

  Fly   112 FMELSFGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQ 176
            |:|||.||....|.:.|:....|...|:|....:|...|.||||:||.||:||...||...|||.
Mouse   116 FLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWD 180

  Fly   177 NCEPAWSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVL 241
            .|....:..:  :|.: .:||.::.|.|                              |:....|
Mouse   181 QCPLVKNASH--TYVE-PECEQSSATTY------------------------------YWYREAL 212

  Fly   242 GLSKGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPG 306
            .::..|.::|.:...:..||.:||.:|.|.:.||:|||||::||::|||||||:...:|.:.|.|
Mouse   213 DITSSISDSGGLNWKMTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNG 277

  Fly   307 ASTGILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNI 371
            :..||....||..:.:...:||.:||.|:||||...:||:|..|||||..|||:.|:::|:|.|.
Mouse   278 SIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINF 342

  Fly   372 ATSFFAGLVIFSIIGFLA------------------------------HELNVDVEKVVD----- 401
            .||..|.||:|:::||.|                              |.:|:....|.|
Mouse   343 FTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKMGNISWDVIPHHINLSAVTVEDYRLVY 407

  Fly   402 -----------------------------QGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGL 437
                                         ||.|||||.:.|.:|..|.||.|:|:||:||:.|||
Mouse   408 DIIQKVKEEEFAVLHLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGL 472

  Fly   438 DSQFALMETVTTAILDRFPNLRQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVL 502
            .|.|..:|.:.|.|:|.| .:|:..:.|:  ..:..:..||.|...||.|::.:.|.|:|...:|
Mouse   473 GSMFGTIEGIITPIVDTF-KVRKEILTVI--CCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLL 534

  Fly   503 LIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVE--YKP 565
            ::.|.|.|.::::||..:|:.|:..|:|.....:.::   ||:||:|..||.:|..:.|.  ..|
Mouse   535 IVVILENIAVSFVYGIDKFIEDLTDMLGFAPSKYYYY---MWKYISPLMLLTLLIASIVNMGLSP 596

  Fly   566 AKYGHYV----------YPMWADAVGW---IVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLL 617
            ..|..::          ||||...|.:   ::.:|||.|:|::
Mouse   597 PGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLAILPVPVVFII---------------------- 639

  Fly   618 QPTAEWGPAGRPCVNLHAERYQSQNYDGVTNTKILIEEEASPKQAANKKDRQLTLDVDVDVECLP 682
                      |.| ||..:  .|.|...||                .|:.|.|...|:::.:...
Mouse   640 ----------RRC-NLIDD--SSGNLASVT----------------YKRGRVLKEPVNLEGDDAS 675

  Fly   683 LATVGKRPGAPKSMGKQGSSGNLQTNAKNGTHKSPTTEISPS 724
            |.. ||.|       .:.||.|...|.......|||.:.:|:
Mouse   676 LIH-GKIP-------SEMSSPNFGKNIYRKQSGSPTLDTAPN 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	204/624 (33%)
Slc6a15	NP_001239259.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..61		2/9 (22%)
Slc6a15	NP_001239259.1	SLC6sbd_SBAT1	61..640	CDD:212091	204/649 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820