Protein Alignment GlyT and Slc6a8

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_598748.1
• Gene: Slc6a8 / 102857
• MGIID: 2147834
• Length: 640
• Species: Mus musculus
• Alignment Length: 680
• Identity: 279/680 - (41%)
• Similarity: 390/680 - (57%)
• Gaps: 72/680 - (10%)

  Fly     4 SSKSGSAGVGGVGG----GGGVVCPSTAISGCASGTALIQLDATGPGAGGAGESEHERGTWTGRF 64
            :.||...|:..|.|    |..:|...........|.|       |.||.|...:...|.|||.:.
Mouse     2 AKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPA-------GLGAPGGRLAVPPRETWTRQM 59

  Fly    65 DFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVY 129
            ||::|.:|::||||||||||||||.||||.||||:.::.::.|:|:.|:|:|.||:...|.:.|:
Mouse    60 DFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVW 124

  Fly   130 RRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQAD 194
             ..||||:|||...:::......||.:::||..:|:..||...|||..|...|:|..|....:.:
Mouse   125 -NICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHE 188

  Fly   195 QCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGLSKGIEETGSIKLSLAA 259
            .|.            ||:.|   |:|...| |.:|.|..|::.|.||.||.|:|..|::...:..
Mouse   189 DCA------------NASLA---NLTCDQL-ADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTL 237

  Fly   260 CLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLAN 324
            ||...|.:|:.|:.|||:|:||:|||||.|||||||:|.||||.||||..||::||.|||.:|.:
Mouse   238 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGS 302

  Fly   325 AQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLA 389
            .|||.||..||||:.:...|.|..|.|||:|:||||||::|:|..|..||||||.|:|||:||:|
Mouse   303 PQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMA 367

  Fly   390 HELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDR 454
            .|..|.:.||.:.|.|||||.||..||.:||:|:||.|||.|||.|||||||..:|...|.:||.
Mouse   368 TEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDL 432

  Fly   455 FPNLRQYKIWVVLSVAI---FGYIGGLGFTTN-----SGMYWLQLMDKYAANWSVLL-IAISECI 510
            .|....::....:|||:   ..::..|...|:     .|||..||.|.|:|:.:.|| .|..||:
Mouse   433 LPASYYFRFQREISVALCCALCFVIDLSMVTDVSGGKGGMYVFQLFDYYSASGTTLLWQAFWECV 497

  Fly   511 LIAWIYGSQRFLNDIQGMIGKR-----SWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGH 570
            ::||:||:.||::||..|||.|     .|.|:||        ||...:.|..||.|.|:|..|.:
Mouse   498 VVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF--------TPLVCMGIFIFNIVYYEPLVYNN 554

  Fly   571 -YVYPMWADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPAGRPCVNLH 634
             ||||.|.:|:||...|..:|.:.|.....:.||..:::  :|.:||.||.  ||        ||
Mouse   555 TYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMA--ERWQHLTQPI--WG--------LH 607

  Fly   635 AERYQSQNYD--GVT-------NTKILIEE 655
            ...|::|:.|  |:|       ::|:::.|
Mouse   608 HLEYRAQDADVRGLTTLTPVSESSKVVVVE 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	248/554 (45%)
		Herpes_BLLF1	<884..1135	CDD:282904
Slc6a8	NP_598748.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/24 (29%)
		SLC6sbd_CT1	52..626	CDD:271397	264/610 (43%)