Protein Alignment GlyT and slc6a4

DIOPT Version :10

• Sequence 1: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_017946918.1
• Gene: slc6a4 / 100493853
• XenbaseID: XB-GENE-22062972
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 242/605 - (40%)
• Similarity: 355/605 - (58%)
• Gaps: 60/605 - (9%)

  Fly     6 KSGSAGVGGVGGGG--GVVCPSTAISGCASGTALIQLDATGPGAGGAGESEHERGTWTGRFDFLL 68
            :|..|...|:..||  |.....|.:..|.:....:|.:.            .||.||:.:.||||
 Frog    72 QSPEAPCNGMRNGGDEGSTPTLTVLPACRAEIQHLQTEI------------GERETWSKKIDFLL 124

  Fly    69 SLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGPVAVYRRFC 133
            |::||:|.|||||||||:||.|||||||||:.||.|..|:||.:|||:.|||...|.::::|:.|
 Frog   125 SVIGYAVDLGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQYHRNGCISIWRKIC 189

  Fly   134 PLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSYAQADQCEA 198
            |||:|:|..:.:::..|..|||.|:||.::|:..||...|||.:|...|:|..|.:|.|
 Frog   190 PLFKGIGYAICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTGNCTNYFQ------ 248

  Fly   199 TNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGL--SKGIEETGSIKLSLAACL 261
                       |::....|:..:         ||||::...||.:  |||:.:.|.|...|..||
 Frog   249 -----------NSSVGWSNSSIS---------PAEEFYTRLVLQIHKSKGLHDLGGISWQLTLCL 293

  Fly   262 FLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPDWKQLANAQ 326
            .|.:|:|:..:.|||::|||||:.||.|||:||.:|.:||.|||||..|:||||.|||::|....
 Frog   294 LLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLALLLIRGATLPGAWRGVLFYLQPDWEKLLTTA 358

  Fly   327 VWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFSIIGFLAHE 391
            ||.|||.||||:|.|.:|.|:..:|||||.||||:|:||.:..|..|||.:|||||:::|::|..
 Frog   359 VWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCYQDALITSTVNCMTSFMSGLVIFTVLGYMAEM 423

  Fly   392 LNVDVEKVV-DQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETVTTAILDRF 455
            .|:||.:|. |.|..|.||.|.|.:..:|.|..:|::||:||:||||||.||.:|.|.||:||.|
 Frog   424 RNLDVSEVAKDTGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEF 488

  Fly   456 PNL----RQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECILIAWIY 516
            |::    |:..:::::||.   ::|.|...|..|.|.::|.::||...:||.:...|.|.::|.|
 Frog   489 PHIWGKRRELFVFLLISVC---FLGALSTLTFGGAYMVKLFEEYATGPAVLTVVFLEAIAVSWFY 550

  Fly   517 GSQRFLNDIQGMIG-KRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPMWADAV 580
            |..:|..|::.|:| ...|||.    |.|..|.|..||||:..........:..:|.||.|...:
 Frog   551 GINQFCRDVREMLGFSPGWFWK----ICWVAICPLFLLFIICSFMSSPPDLRLFNYQYPSWTVVL 611

  Fly   581 GWIVG-----LLPVLVIFLV 595
            |:.:|     .:|..:::|:
 Frog   612 GYCIGTSSFICVPAYMVYLL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..597	CDD:395155	232/552 (42%)
		Herpes_BLLF1	<884..1135	CDD:282904
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:397524	6/18 (33%)
		SLC5-6-like_sbd	113..649	CDD:444915	232/552 (42%)