DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GlyT and slc6a7

DIOPT Version :9

Sequence 1:	NP_611836.2	Gene:	GlyT / 37772	FlyBaseID:	FBgn0034911	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_002940131.3	Gene:	slc6a7 / 100487063	XenbaseID:	XB-GENE-479449	Length:	634	Species:	Xenopus tropicalis

Alignment Length:	638	Identity:	279/638 - (43%)
Similarity:	408/638 - (63%)	Gaps:	75/638 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ESEHERGTWTGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELS 116
            |...:||.|:|:.|||||.:||.|||||||||||..|.|||||||||:.|||.|.|:||.|||||
Frog    32 EYPEDRGNWSGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLIPYFIMLAICGIPLFFMELS 96

  Fly   117 FGQYAALGPVAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPA 181
            .||:::|||:||: :..|||:|:|.||:|:.|:|.:|||:|||:.:||:|||....|||::|...
Frog    97 LGQFSSLGPLAVW-KISPLFKGVGMGMLLIVALVAIYYNMIIAYVLFYLFASLTSSLPWEHCGNW 160

  Fly   182 WSTKYCFSYAQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGL--S 244
            |:|..|..:            :.:|..::|.....:|..:         |:|||::.:||.:  |
Frog   161 WNTDLCLDH------------HVIRASNSALLVNISNTVS---------PSEEYWSRYVLHIQGS 204

  Fly   245 KGIEETGSIKLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGAST 309
            .||.:.|.::..|..||.|:||||:||:.|||:||||||||||.|||::||:|.:|||||.||..
Frog   205 SGIGDPGQLRWKLCLCLLLSWTIVYLCILKGVKSSGKVVYFTATFPYIILVMLLIRGVTLEGAWI 269

  Fly   310 GILFYLTPDWKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATS 374
            ||.|||||.::.|..::||.:||:|||::|...:|||:|.:|||.|..|.|:|:.||...|..||
Frog   270 GIKFYLTPQFEHLLTSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAFTS 334

  Fly   375 FFAGLVIFSIIGFLAHELNVDVEKVVDQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDS 439
            ..||..|||::|:::.||.|.|::|...|.||||:|||:.:|.||:||.|:.|||.|||||||||
Frog   335 ILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDS 399

  Fly   440 QFALMETVTTAILDRFP-NLRQYK--IWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSV 501
            |||.|||:.|||.|.|| .||..|  ...::.||:|  :.||...|:.|||||.|:|.|:|.:.:
Frog   400 QFAFMETIVTAITDEFPYYLRPKKAVFSAIICVALF--LLGLILATDGGMYWLVLLDDYSAGFGL 462

  Fly   502 LLIAISECILIAWIYGSQRFLNDIQGMIGKRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPA 566
            |:|.|:.|:.::.:||.:.|..|||.|:|.:.   ..::...|.:::|.||:.:|.::.::|:|:
Frog   463 LVIVITFCLSVSRVYGIKNFCRDIQMMLGFKP---GLYFKACWIFLSPVTLMCLLAYSILKYQPS 524

  Fly   567 KYGHYVYPMWADAVGWIVGLLPVLVI---FLVAFQE----IWRAPMSLSFRDRIKHLLQPTAEWG 624
            :||.|.:|:|::|:|.::|||..::|   .|||..:    :|         :||:...:|..:||
Frog   525 QYGSYKFPLWSEALGILMGLLSCMMIPIGMLVAILKEEGSLW---------ERIRQASRPAMDWG 580

  Fly   625 P--------------AG----RPCVNLHAERYQSQNYDGVT---NTKILIEEE 656
            |              ||    :|.: :|..:     |.|:|   ||.|.:::|
Frog   581 PSMEENRTGMYVNTLAGSQSPKPLM-VHMRK-----YGGITSYENTAIEVDKE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlyT	NP_611836.2	SNF	57..603	CDD:249680	261/557 (47%)
slc6a7	XP_002940131.3	SLC5-6-like_sbd	37..581	CDD:382020	265/579 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	562	1.000	Domainoid score	I236
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49529
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010