DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4797 and ITR2

DIOPT Version :9

Sequence 1:	NP_726368.2	Gene:	CG4797 / 37770	FlyBaseID:	FBgn0034909	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_014538.2	Gene:	ITR2 / 854050	SGDID:	S000005463	Length:	609	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	114/547 - (20%)
Similarity:	200/547 - (36%)	Gaps:	107/547 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KKASYSSRKLSTIDEQDDDAANRRGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEI 94
            ||:..|:..:.....||:|..:.|                           |::..:.|.:.|.:
Yeast    60 KKSPVSTSTMQIKSRQDEDEDDGR---------------------------IVIKPVNDEDDTSV 97

  Fly    95 PID--------VETGSWIASVH-----------------------------------SLATPFGS 116
            .|.        :.|.:::||:.                                   :.||..|:
Yeast    98 IITFNQSISPFIITLTFVASISGFMFGYDTGYISSALISINRDLDNKVLTYGEKELITAATSLGA 162

  Fly   117 LL----SGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYI 177
            |:    :|..||..|||..|:.|.:..|:|......|.....:...|.:.||..||......::|
Yeast   163 LITSVGAGTAADVFGRRPCLMFSNLMFLIGAILQITAHKFWQMAAGRLIMGFGVGIGSLISPLFI 227

  Fly   178 AETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY-----WRSVAWCANVLPLLSMVSISFIPET 237
            :|.|...:|..|.....:..:.|.|:.|..|:.:.     ||.:...:.:..:|......|:|:|
Yeast   228 SEIAPKMIRGRLTVINSLWLTGGQLIAYGCGAGLNHVKNGWRILVGLSLIPTVLQFSFFCFLPDT 292

  Fly   238 PAWLLRNGHEKRALQAL--SFLR-GSEISAQK--ELNDMKQRLAKERVTTKTNENIFQLCCQRVA 297
            |.:.:..|..|||...|  |::. ..||..||  ||:.:.|.:..:...||....:.:|......
Yeast   293 PRYYVMKGDLKRAKMVLKRSYVNTEDEIIDQKVEELSSLNQSIPGKNPITKFWNMVKELHTVPSN 357

  Fly   298 IKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMV-FCVVLIFV 361
            .:.|:|......:|.|:|...:::::..:....|.:..|..:.|.:....|...:. ||:..|
Yeast   358 FRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKI-- 420

  Fly   362 RRRRIMIVSGIGSGLFCLVLSVYQY----ARFD--QPKMSYDVFVGAGCLLGYIIFNTALMVMPG 420
             .||.:::.|:......||:....:    .:|:  ...::.|.|...|.::  |:|.........
Yeast   421 -GRRYILLIGLPGMTVALVICAIAFHFLGIKFNGADAVVASDGFSSWGIVI--IVFIIVYAAFYA 482

  Fly   421 IMIG-------ELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLT 478
            :.||       ||||..:||.......|:......:.|..|..:...:...|.|..|...:.|.|
Yeast   483 LGIGTVPWQQSELFPQNVRGVGTSYATATNWAGSLVIASTFLTMLQNITPTGTFSFFAGVACLST 547

  Fly   479 AFMCLFQPETKGRSLEHIE----DYFN 501
            .|.....||..|..||.::    |.||
Yeast   548 IFCYFCYPELSGLELEEVQTILKDGFN 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4797	NP_726368.2	MFS	64..484	CDD:119392	99/490 (20%)
CG4797	NP_726368.2	Sugar_tr	89..497	CDD:278511	102/478 (21%)
ITR2	NP_014538.2	MFS_HMIT_like	115..556	CDD:340918	94/445 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I806
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810