DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4797 and MPH3

DIOPT Version :9

Sequence 1:	NP_726368.2	Gene:	CG4797 / 37770	FlyBaseID:	FBgn0034909	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_012694.1	Gene:	MPH3 / 853625	SGDID:	S000003921	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	643	Identity:	131/643 - (20%)
Similarity:	227/643 - (35%)	Gaps:	208/643 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VERDDE---------YLKFVPHTMSYQVVPGSEFQCKKASYSSRKL------STIDEQDDDAANR 52
            :|.||:         :::|.|.|              :|...|.|:      :|.|.::.|.:.|
Yeast    33 IEMDDQTKKDGLDIVHVEFSPDT--------------RAPSDSNKVITEIFDATEDAKEADESER 83

  Fly    53 RGMMHQILATCAVLLLSAGCGMPIGFSAILLPQ------------LMDNNSTEI-------PI-- 96
                                |||:..:....|:            :|:...|.|       ||
Yeast    84 --------------------GMPLATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQ 128

  Fly    97 ------DVETGSWIASV---------HSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTL 146
                  :.:||.|..|.         :......|..|:||..|.:|.|.|||:::..|......|
Yeast   129 RKFGSQNDKTGEWEISASWQIGLTLCYMAGEIVGLQLTGPSVDLVGNRYTLIIALFFLAAFTFIL 193

  Fly   147 AIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVA------YSSGIL--- 202
            ....|:.::...:.|||...|........|.:|.....||..|.....:.      :::||:
Yeast   194 YFCNSLGMIAVGQALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNS 258

  Fly   203 --------MVYSLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNG---HEKRALQALSF 256
                    :.|.|...:.|        :||:...:.|.|.||:|.||::.|   ..:|:|:....
Yeast   259 QKKYADSELGYKLPFALQW--------ILPVPLALGIFFAPESPWWLVKKGRFDEARRSLRRTLS 315

  Fly   257 LRG--SEISAQKELNDMKQRLAKE-RVTTKTNENIFQLCCQ------RVAIKPLV---------I 303
            .:|  .||....|::.:|..:.|| |:|:|  |..:..|.:      |..|..|.         |
Yeast   316 GKGPEKEILVTLEVDKIKVTIDKEKRLTSK--EGSYSDCFEDKINRRRTRITCLCWAGQATCGSI 378

  Fly   304 VIVFS--------LLQMFSGTFIVIFYAVDMISEFGAEFDSKQ------AAIATAVVRVICCMVF 354
            :|.:|        :....|.||.:|.|.:.:.:.|.:.:.||.      .|...|         |
Yeast   379 LIGYSTYFYEKAGVSTEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLYAFGLA---------F 434

  Fly   355 CVVLIFVRRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYDVFVGAGCLLGYIIFNTALMVMP 419
            ..::.|       |:.|:|    |              ..::...:|:|.||..:.|...|.:.|
Yeast   435 QTIVFF-------IIGGLG----C--------------SSTHGSKMGSGSLLMAVAFFYNLGIAP 474

  Fly   420 GI--MIGELFPARIRGRT---------AGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVS 473
            .:  ::.|:..:|:|.:|         ...:..|:.:...:.:||:    ......|.|  :||.
Yeast   475 VVFCLVSEMPSSRLRTKTIILARNTYNVVSIICSVLILYQLNSKKW----NWGAKSGFF--WGVL 533

  Fly   474 SFLLTAFMCLFQPETKGRSLEHIEDYFN-GDNWLWFRRDRGYKTVNLQPL---EPLKD 527
            .|....:..:..|||.|::...|.:.|. |.:      .|.:|:..:.|.   .|.||
Yeast   534 CFCTLIWAVVDLPETAGKTFVEINELFKLGVS------ARKFKSTKVDPFVVKTPPKD 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4797	NP_726368.2	MFS	64..484	CDD:119392	105/518 (20%)
CG4797	NP_726368.2	Sugar_tr	89..497	CDD:278511	104/494 (21%)
MPH3	NP_012694.1	SP	72..556	CDD:273317	113/553 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810