Protein Alignment pippin and ITR1

DIOPT Version :10

• Sequence 1: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_010785.1
• Gene: ITR1 / 852108
• SGDID: S000002905
• Length: 584
• Species: Saccharomyces cerevisiae
• Alignment Length: 539
• Identity: 119/539 - (22%)
• Similarity: 215/539 - (39%)
• Gaps: 52/539 - (9%)

  Fly     2 SVERDDEYLKFVPHTMSYQVVPGSEFQCKKASYSSRKLSTIDEQDDDAANRRGMMHQILATCAVL 66
            |||.:.|:..  |.......:...|.|...||....::......|:|..:.....:|.|:...:.
Yeast    26 SVEFNSEHDS--PSKRGKITLESHEIQRAPASDDEDRIQIKPVNDEDDTSVMITFNQSLSPFIIT 88

  Fly    67 L--LSAGCGMPIGFSAILLPQLMDNNSTEIPIDVET---GSWIASVHSLATPFGSLLSGPLADYL 126
            |  :::..|...|:....:...:.:..|::...|.|   ...:.:..||.....|:.:|..||..
Yeast    89 LTFVASISGFMFGYDTGYISSALISIGTDLDHKVLTYGEKEIVTAATSLGALITSIFAGTAADIF 153

  Fly   127 GRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIG 191
            ||:|.|:.|.:..::|......|.:...:...|.:.||..||......::|:|.|...:|..|..
Yeast   154 GRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTV 218

  Fly   192 APYVAYSSGILMVYSLGSMMYWRSVAWCANVLPLLSMV-------SISFIPETPAWLLRNGHEKR 249
            ...:..:.|.|:.|..|:.:.:.:..|  .:|..||::       .:.|:|:||.:.:..|...|
Yeast   219 INSLWLTGGQLVAYGCGAGLNYVNNGW--RILVGLSLIPTAVQFTCLCFLPDTPRYYVMKGDLAR 281

  Fly   250 ALQAL--SFLRGSEISAQK---ELNDMKQRLAKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSL 309
            |.:.|  |:...||...::   ||..:.|.:..:.|..|....|.:|......::.|:|......
Yeast   282 ATEVLKRSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQA 346

  Fly   310 LQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIF----VRRRRIMIVS 370
            :|.|:|...:::::..:....|.:..|..:.|.:..     ..:|.:|..|    :.||.|:::.
Yeast   347 IQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGT-----NFIFTLVAFFSIDKIGRRTILLIG 406

  Fly   371 GIGSGLFCLVLSV---YQYARFDQPKMSYDVFVGAG------CLLGYIIFNTALMVMPGI----- 421
            ..|..:..:|.|:   :...:||.   :..|.|.:|      .::.:||...|...: ||
Yeast   407 LPGMTMALVVCSIAFHFLGIKFDG---AVAVVVSSGFSSWGIVIIVFIIVFAAFYAL-GIGTVPW 467

  Fly   422 MIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQP 486
            ...||||..:||.......|:......:.|..|..:...:...|.|..|...|.|.|.|.....|
Yeast   468 QQSELFPQNVRGIGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAFFAGLSCLSTIFCYFCYP 532

  Fly   487 ETKGRSLEHIE----DYFN 501
            |..|..||.::    |.||
Yeast   533 ELSGLELEEVQTILKDGFN 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	103/470 (22%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	97/451 (22%)