Protein Alignment pippin and SLC2A10

DIOPT Version :10

• Sequence 1: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_011527362.1
• Gene: SLC2A10 / 81031
• HGNCID: 13444
• Length: 562
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 123/546 - (22%)
• Similarity: 209/546 - (38%)
• Gaps: 144/546 - (26%)

  Fly    59 ILATCA-VLLLSAGCGMPIGF-----SAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSL 117
            :|..|| |.||.   |:..|:     |..|||..:|...:.:..:...||.:     |.....||
Human    28 VLPLCASVSLLG---GLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLL-----LGALLASL 84

  Fly   118 LSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAE 182
            :.|.|.|..||::.::.|.:.||.|..||.:|.|:..::..|.:.|||..:......:|::|...
Human    85 VGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVG 149

  Fly   183 PNLRSLLIGAPYVAYSSGILMVYSL-----GSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLL 242
            |..|.:|:.......:.|||:.|:|     |:...||.:...|....:|..:|:.|:|.
Human   150 PRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPA------ 208

  Fly   243 RNGHEKRAL-QALSFLRGSEISAQKELNDMKQRL-------AKERVTTKTNENIFQLCCQRVAIK 299
              |.::.|. :.|..|:|.|   ..:|...:.|.       |::.:..:|
Human   209 --GTDETATHKDLIPLQGGE---APKLGPGRPRYSFLDLFRARDNMRGRT--------------- 253

  Fly   300 PLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQ--AAIATAVVRVICCMVFCVVLIFVR 362
              .:.:...|.|..:|...|:.||..:.|..|....|..  |::....|:|...:....::....
Human   254 --TVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAG 316

  Fly   363 RRRIMI---------VSGIG---------SGLFCL------------------------------ 379
            ||.:::         |||||         ||..||
Human   317 RRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTN 381

  Fly   380 ------VLSVYQ----YARFDQPKMSYDVFVGAG--------------------CLLGYI-IFNT 413
                  :||..:    :.|...|.....:.:.:.                    ||:.:: .|:.
Human   382 EDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSF 446

  Fly   414 ALMVMPGIMIGELFPARIRGRTAGGVFA---SMNVALFIF-AKKFPALQAMLKMRGVFLVFGVSS 474
            ....:..:::.|::|..||||    .||   |.|.|..:| :..|..|...:.:...||::|:::
Human   447 GFGPVTWLVLSEIYPVEIRGR----AFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTA 507

  Fly   475 FLLTAFMCLFQPETKGRSLEHIEDYF 500
            .|...|:.||.|||||:||..|:..|
Human   508 VLGLGFIYLFVPETKGQSLAEIDQQF 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	121/539 (22%)
SLC2A10	XP_011527362.1	MFS_GLUT10_Class3	31..529	CDD:340994	120/537 (22%)