Protein Alignment pippin and SLC2A5

DIOPT Version :10

• Sequence 1: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_003030.1
• Gene: SLC2A5 / 6518
• HGNCID: 11010
• Length: 501
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 136/503 - (27%)
• Similarity: 224/503 - (44%)
• Gaps: 68/503 - (13%)

  Fly    45 QDDDAANRRGMMHQILATCAVLLLSAGCGMPIGFS-------AILLPQLMDNNST---------- 92
            :..|.:.:.|.:..:|| .|.|:.:.|.....|::       |:|:.|..  |.|
Human     2 EQQDQSMKEGRLTLVLA-LATLIAAFGSSFQYGYNVAAVNSPALLMQQFY--NETYYGRTGEFME 63

  Fly    93 EIPIDVETGSWIASVHSLATPF----GSLLSGPLADYLGRRRTL----ILSVIP-LLLGWSTLAI 148
            :.|:   |..|..:|...  ||    ||||.|||.:..||:..|    |.|::| :|:|.|  .:
Human    64 DFPL---TLLWSVTVSMF--PFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCS--RV 121

  Fly   149 AKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILM--VYSLGSMM 211
            |.|.:::|.:|.|.|...|:......:|:.|.|..|||..|...|.:..:.|||:  ::.|.:::
Human   122 ATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLL 186

  Fly   212 Y----WRSVAWCANVLPLLSMVSISFIPETPAWLL-RNGHEKRALQALSFLRGSEISAQKELNDM 271
            .    |..:.....|...|.::.:.|.||:|.:|| :...|..|.:||..|||.: |..:|:.::
Human   187 ANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWD-SVDREVAEI 250

  Fly   272 KQRLAKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDS 336
            :|....|:.....  ::.:|...|.....|:.:||....|..||...:.:||..:....|...:.
Human   251 RQEDEAEKAAGFI--SVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEH 313

  Fly   337 KQAAIA-TAVVRVICCMVFCVVLIF-VRRRRIMIVSGIGSGLF-CLVLSVYQYARFDQPKMSYDV 398
            .|...| |..|.|:  |.||.|.:. :..||::::.|....|. |.||:.   |...|..:|:..
Human   314 VQYVTAGTGAVNVV--MTFCAVFVVELLGRRLLLLLGFSICLIACCVLTA---ALALQDTVSWMP 373

  Fly   399 FVGAGCLLGYIIFNTAL--MVMPGIMIGELF--PARIRGRTAGGV---FASMNVALFIFAKKFPA 456
            ::...|::.|:| ..||  ..:|.::|.|:|  .:|......||.   .::..|.|.     ||.
Human   374 YISIVCVISYVI-GHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLI-----FPF 432

  Fly   457 LQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYFNGDN 504
            :|..|.... |:||.|...|.|.::.|..||||.::...|...|...|
Human   433 IQEGLGPYS-FIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMN 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	131/478 (27%)
SLC2A5	NP_003030.1	MFS_GLUT_Class2	23..471	CDD:340990	127/471 (27%)