DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4797 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_726368.2	Gene:	CG4797 / 37770	FlyBaseID:	FBgn0034909	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	505	Identity:	142/505 - (28%)
Similarity:	222/505 - (43%)	Gaps:	73/505 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IDEQDDDAANRRGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMDNNS--------------T 92
            |..:|.:...:|.....:||..:.:|.|...|..||  .|..||.:...|              :
Human     8 IGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIG--VINAPQKVIEQSYNETWLGRQGPEGPS 70

  Fly    93 EIPIDVETGSWIASV--HSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAK---SI 152
            .||....|..|..||  .|:.....|.|.|.::.:|||:|.::::.:..:||.|.:.:|.   |.
Human    71 SIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASY 135

  Fly   153 KVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLG--SMMYWRS 215
            :::|..|||.|..:|:..|...:|:.|.|..:||..|.....:|...|||:...||  |::...|
Human   136 EMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTAS 200

  Fly   216 VAW----CANVLP-LLSMVSISFIPETPAWL-LRNGHEKRALQALSFLRG-SEIS-AQKELNDMK 272
            : |    ...||| ||.:|.:.|.||:|.:| :....|..|.::|..|.| :::| ...||.|.|
Human   201 L-WPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEK 264

  Fly   273 QRLAKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSK 337
            ::|.:||..     ::.||...|...:||:|.:|..|.|..||...|.:|:..:....|.    .
Human   265 RKLERERPL-----SLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGV----G 320

  Fly   338 QAAIATAVVRVICCMVFCVVLIFVRR--RRIMIVSGIGSGLFCLVLSVYQYARFDQ-PKMSYDVF 399
            |.|.||....|:..:...|.::.|.|  ||.:.:.|:.....|.:|........:: |.|||
Human   321 QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSY--- 382

  Fly   400 VGAGCLLGYIIFNTALMVMPG----IMIGELFPARIRGRTAGGVFASMNVA-------LFIFAKK 453
            |....:.|::.|   ..:.||    .::.|||       :.|...|:|.||       .||....
Human   383 VSIVAIFGFVAF---FEIGPGPIPWFIVAELF-------SQGPRPAAMAVAGFSNWTSNFIIGMG 437

  Fly   454 FPALQAMLKMRG--VFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYFN 501
            |   |.:.:..|  |||:|.|.......|..|..|||:||:.:.|...|:
Human   438 F---QYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4797	NP_726368.2	MFS	64..484	CDD:119392	129/464 (28%)
CG4797	NP_726368.2	Sugar_tr	89..497	CDD:278511	127/452 (28%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13		1/4 (25%)
		Sugar_tr	27..483	CDD:306568	137/483 (28%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910