DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4797 and itr2

DIOPT Version :9

Sequence 1:	NP_726368.2	Gene:	CG4797 / 37770	FlyBaseID:	FBgn0034909	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_593320.1	Gene:	itr2 / 2541827	PomBaseID:	SPAC20G8.03	Length:	557	Species:	Schizosaccharomyces pombe

Alignment Length:	550	Identity:	121/550 - (22%)
Similarity:	218/550 - (39%)	Gaps:	87/550 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RDDEYLKFVPHTMSYQVVPGSEFQCKKASYSSRKLSTIDEQDDDAANRRG------------MMH 57
            |..|..|.||.:...:.:|...        :..:.:..|.|.::.|:..|            .:.
pombe    28 RPSETKKKVPFSEDMREIPSLP--------NEEEANATDPQANEVADENGEGFEAEKISSWIWVL 84

  Fly    58 QILATCAVLLLSAGCGMPIGFSAIL---LPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLS 119
            ..:|..:.||.....|:..|..|:|   |..::.:...|:         |.|..|.|....:..|
pombe    85 SAVAGISGLLFGYDTGVISGALAVLGSDLGHVLSSGQKEL---------ITSATSFAALISATTS 140

  Fly   120 GPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPN 184
            |.|||::||:|.|:.:....::|...:|.::::.:::..||:.|:..|:......:||.|.|...
pombe   141 GWLADWVGRKRLLLCADAIFVIGSVIMAASRNVAMMVVGRFIVGYGIGLTSLIVPMYITELAPAR 205

  Fly   185 LRSLLIGAPYVAYSSGILMVYSLGSMMY-----WRSVAWCANVLPLLSMVSISFIPETPAWLLRN 244
            ||..|:....|..:.|.|:.|||.:...     ||.:........|..::|:.:.||:|.:|||:
pombe   206 LRGRLVIIYVVFITGGQLIAYSLNAAFEHVHQGWRIMFGIGAAPALGQLISLFWTPESPRYLLRH 270

  Fly   245 GHEKRALQALSFL----RGSEISAQKELNDMKQRLAKERVTTKTNE-NIFQLCCQRVAI------ 298
            .|.::..:.||.:    :.:||:       .|..|.:|.|.....| |.||.....:.:
pombe   271 NHVEKVYKILSRIHPEAKPAEIA-------YKVSLIQEGVKVDFPEGNKFQHFFHSLKVLFTVPS 328

  Fly   299 --KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVV-LIF 360
              :.|.|.......|.||||..:.:::..:....|.     :.:|:.::|......||.:| .:|
pombe   329 NRRSLFIGCFLQWFQQFSGTNAIQYFSAIIFQSVGF-----KNSISVSIVVGATNFVFTIVAFMF 388

  Fly   361 V----RRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYDVFVGAGCLLGYIIFNTALMVMPGI 421
            :    |||.::..|.:......|....|.:...|..:.:...:       .|::..:.::.:...
pombe   389 IDRIGRRRILLCTSAVMIAGLALCAIAYHFLPADTTQNTNSGW-------QYVVLASIIIFLASY 446

  Fly   422 MIG---------ELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSF-- 475
            ..|         ||||..:|...||...|...|...|.:..|..:...:...|.|.:|....|
pombe   447 ASGIGNIPWQQAELFPMEVRALGAGFSTAINWVGNLIISASFLTMMESITPTGTFALFAGFCFVG 511

  Fly   476 LLTAFMCLFQPETKGRSLEHIEDYFNGDNW 505
            |:|::..  .||..|.|:|:|........|
pombe   512 LVTSYFT--YPELAGMSIENIHKLLEKGFW 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4797	NP_726368.2	MFS	64..484	CDD:119392	103/456 (23%)
CG4797	NP_726368.2	Sugar_tr	89..497	CDD:278511	101/441 (23%)
itr2	NP_593320.1	Sugar_tr	84..534	CDD:278511	110/479 (23%)
itr2	NP_593320.1	MFS	86..519	CDD:119392	104/462 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810