Protein Alignment pippin and hmit-1.2

DIOPT Version :10

• Sequence 1: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_507624.1
• Gene: hmit-1.2 / 180206
• WormBaseID: WBGene00013074
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 519
• Identity: 111/519 - (21%)
• Similarity: 189/519 - (36%)
• Gaps: 123/519 - (23%)

  Fly    93 EIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIF 157
            |:.:.:..|  :|:|       |:..||..:|..||:..:|.|.:..:.|....|:|.:..|::.
 Worm    69 EVIVSITPG--MAAV-------GAWFSGAGSDRYGRKPIIIGSTLIFVCGAVICAVAWTKIVMLI 124

  Fly   158 ARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMM-YWR--SVAW- 218
            .|...|...|.......||:.|.:..::|..|:.|..:..|.|.::...:|.:. ||.  ::.|
 Worm   125 GRIFLGVGIGFASMVVPVYLGEASPTHVRGTLVSAFAMMISFGQVVANIMGGVFSYWEPYTIGWR 189

  Fly   219 ----CANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEIS-AQKELNDMKQRLAKE 278
                .|.:..|:..|...|:||||.||..|||.::|.|.|..:.|.... .:.||.::| ..|:|
 Worm   190 LMFAFAGIPALIQFVCFIFLPETPRWLYENGHTEQAEQVLEKIYGGNTEWIEYELAEIK-TYAEE 253

  Fly   279 RVTTKTNENIFQLCCQRVAIKPLVIVIVF--SLLQMF---SGTFIVIFYAVDMISEFGAEFDSKQ 338
            |......|........|:...|.|:...|  |:||.|   :|...:::|..|:|...|.|  :..
 Worm   254 RQKQMEEEKKSGPVIWRILKTPHVLKACFIGSMLQAFQQLAGINTILYYTADIIRSAGIE--NYH 316

  Fly   339 AAIATAVVRVICCMVFCVVLIF----VRRRRIMIVS-----------GI---------------- 372
            ..|..:|:..||.::.....:|    :.||::.:.|           |:
 Worm   317 TIIWISVILSICNLIGPFAPMFFIEKLGRRKLFLFSCAGVVVSLVLIGVSFLLVGNDSAPNFDRS 381

  Fly   373 -----------GSGLFCLVLS-------------------------------VYQYAR------- 388
                       |....||:||                               |..|:.
 Worm   382 AYLLAGNYQSNGEAESCLMLSNCDSCVTSEHCGFCEDSETRTGFCLPVDHNDVTLYSSTGLCTNG 446

  Fly   389 FDQPKMSYD-----VFVGAGCLLGYII------------FNTALMVMPGIMIGELFPARIRGRTA 436
            .|:...|:.     |:....|...|.|            |:.....:|.::..|.:|...|....
 Worm   447 LDKSNSSFPNATSYVWQKHHCTTSYTILPIVMMGVYLLTFSCGFTSLPWVLNSEFYPMWARSTCV 511

  Fly   437 GGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYF 500
            .....|..|...|.|..:.:|...:...|.|.::.:.:.:...|:....|||.|.|::.:|..|
 Worm   512 SISTLSNWVFNLIIALTYLSLTHAITKYGAFWLYAIFTIIAFIFIYFLVPETTGYSIDEVEMLF 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	109/512 (21%)
hmit-1.2	NP_507624.1	MFS	32..562	CDD:475125	104/504 (21%)