Protein Alignment pippin and hmit-1.1

DIOPT Version :10

• Sequence 1: NP_726368.2
• Gene: pippin / 37770
• FlyBaseID: FBgn0034909
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_507623.1
• Gene: hmit-1.1 / 180205
• WormBaseID: WBGene00013073
• Length: 606
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 135/596 - (22%)
• Similarity: 219/596 - (36%)
• Gaps: 160/596 - (26%)

  Fly    32 ASYSSRKLSTIDEQDDDA-ANRRGMMHQILATCAVLLLSAGCGMPIGF-----SAILL-----PQ 85
            |::||      ..||..| ..:.|:...|||..:|:     .|...|:     ||.:|     |.
 Worm     5 AAFSS------SGQDKPAHTPKLGLFVYILAAASVI-----GGFLFGYDTSVVSAAMLYMPDAPG 58

  Fly    86 L--MDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAI 148
            |  ||....|:.:.:..|  :|:|       |||:||..:||:|||:.::.:.....:|  .|..
 Worm    59 LKPMDTVWQEVLVSISPG--MAAV-------GSLMSGTSSDYIGRRKVILGASAIFTIG--ALVC 112

  Fly   149 AKSIK--VVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMV------- 204
            |.|:.  :::..|.|.|.|.|.......||:.|||..::|.:|:.|..:..|.|.::.
 Worm   113 AASVNKIMLLVGRVLLGIAIGFASMIVPVYLGETAPTHVRGMLVAAFALMISFGQVVANITGGAF 177

  Fly   205 -----YSLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISA 264
                 |::|    ||.:...|.|..::..|...|:||||.||..||.|....:.|.    ...:.
 Worm   178 SYIDPYNVG----WRLMFAFAAVPSIIQFVCFMFLPETPRWLYENGFETETREVLE----KVYNG 234

  Fly   265 QKEL--NDMKQRLAKERVTTKTNENIFQL--CCQRVAIKPLVIVIVF--SLLQMF---SGTFIVI 320
            .||.  .:|.:.:|......|.||.....  ...|:...|.|:...|  |:||.|   :|...::
 Worm   235 DKEWVEYEMAEIIAFNEDQAKENEKAHASGPVIWRILKTPHVLKACFIGSMLQAFQQLAGINTIL 299

  Fly   321 FYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVV---LIFVRRRRIMIVSGIGSGLFCLV-- 380
            :|..|:|...|  ..:....|..:|:..:|..:...|   ||....|||:.:...|..:..||
 Worm   300 YYTADIIRSSG--ISNNHTTIWISVLLSLCNFIGPFVPMSLIEKVGRRIIFLFSCGLVVLSLVFI 362

  Fly   381 --------------LSVYQY--------------------------------------------A 387
                          |...||                                            |
 Worm   363 GVAFLLVNHDSAATLPANQYGSNFNSSYPDAKGCMAYSNCDYCVTTDACGFCHDANTKQGYCLPA 427

  Fly   388 RFDQPKM---------------------------SYDVFVGAGCLLGYIIFNTALMVMPGIMIGE 425
            .||.|::                           .|.:.....|.:..:.|::....:|.::..|
 Worm   428 GFDNPEVYSSTGSCTNSNGSIANNFKWEKYYCDTKYTLLPIIACGVYLLTFSSGFTSLPWVLNSE 492

  Fly   426 LFPARIRGRTAGGVFASMN-VALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETK 489
            .:|...|. |...:..:.| |...|.|..:.:|..::...|.|.::...:.:...|:....||||
 Worm   493 FYPMWARS-TCVAISTTSNWVFNLIIALTYLSLTQVIGKYGAFWLYAGLTVIAFIFILFLVPETK 556

  Fly   490 GRSLEHIEDYF 500
            |.|:|.:|..|
 Worm   557 GYSIEEVEMLF 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pippin	NP_726368.2	MFS_GLUT6_8_Class3_like	59..495	CDD:340916	125/561 (22%)
hmit-1.1	NP_507623.1	MFS_HMIT_like	31..554	CDD:340918	116/549 (21%)