DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4797 and SLC2A12

DIOPT Version :9

Sequence 1:	NP_726368.2	Gene:	CG4797 / 37770	FlyBaseID:	FBgn0034909	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_660159.1	Gene:	SLC2A12 / 154091	HGNCID:	18067	Length:	617	Species:	Homo sapiens

Alignment Length:	539	Identity:	118/539 - (21%)
Similarity:	203/539 - (37%)	Gaps:	126/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 GCGM--------------PIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGP 121
            ||||              .:|:...::...:....|.:.:.......:.|...:.....||..|.
Human    35 GCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGV 99

  Fly   122 LADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLR 186
            |.|..|||..:|||...|.||...|.::.|..|:|..|...|.:..:......|||||.|..:.|
Human   100 LIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRR 164

  Fly   187 SLLIGAPYVAYSSGILMV----YSLGSMMY-WRSVAWCANVLPLLSMVSISFIPETPAWLLRNGH 246
            .||:....:....|||..    |:..::.: |:.:......|.:|..:::.|:|.:|.:|:..|.
Human   165 GLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQ 229

  Fly   247 EKRALQALSFLRGSEISAQKELNDMKQRLAKERVTT-----KTNENIFQLCCQRVAIKPLVIVIV 306
            |..|.:.|..||... ...:||..:|..|..|...:     ::.:|:      |..|. :.:.:|
Human   230 EGAASKVLGRLRALS-DTTEELTVIKSSLKDEYQYSFWDLFRSKDNM------RTRIM-IGLTLV 286

  Fly   307 FSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAA----IATAVVRVICCMVFCVVLIFVRRR--- 364
            |.:  ..:|...::|||..::...|  |.|.:||    ....||:||..:...:::..|..:
Human   287 FFV--QITGQPNILFYASTVLKSVG--FQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFL 347

  Fly   365 ----RIMIVSGIGSGLFCLVL-----------------------------------------SVY 384
                .:|..|.:..|:..|.:                                         .:.
Human   348 CIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGIS 412

  Fly   385 QYARFDQPKMSYDV----------FVGAG-------------------------CLLGYI-IFNT 413
            .::|.....:..||          .:.||                         .||.|: .|:.
Human   413 SHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSI 477

  Fly   414 ALMVMPGIMIGELFPARIRGRTAGGVFASMNVAL-FIFAKKFPALQAMLKMRGVFLVFGVSSFLL 477
            .|..||.:::.|:||..|||| |..:.:|||..: .:.:..|..:..::.:..|..::.:.|...
Human   478 GLGPMPWLVLSEIFPGGIRGR-AMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLAS 541

  Fly   478 TAFMCLFQPETKGRSLEHI 496
            ..|:.:|.|||||.|||.|
Human   542 LLFVVMFIPETKGCSLEQI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4797	NP_726368.2	MFS	64..484	CDD:119392	108/525 (21%)
CG4797	NP_726368.2	Sugar_tr	89..497	CDD:278511	113/507 (22%)
SLC2A12	NP_660159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
SLC2A12	NP_660159.1	Sugar_tr	44..561	CDD:306568	114/530 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820