DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and SNRNP40

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_004805.2	Gene:	SNRNP40 / 9410	HGNCID:	30857	Length:	357	Species:	Homo sapiens

Alignment Length:	307	Identity:	70/307 - (22%)
Similarity:	125/307 - (40%)	Gaps:	61/307 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 PSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENH--------PIRSLQYSVTGDMILVIS 248
            |:|:.|.|...|..:..|:..|            .|:|:        .:..|.|:..|.|:...|
Human    76 PNGSTLASAGFDRLILLWNVYG------------DCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128

  Fly   249 GNAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNR--EQFLTAALDGTLRIW 311
            .:....|.|.:..|:::            |.|||.:.:.| | :|..|  :...|.:.|||:::|
Human   129 TDKTVAVWDSETGERVK------------RLKGHTSFVNS-C-YPARRGPQLVCTGSDDGTVKLW 179

  Fly   312 QGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAH 376
            . ::.|..:|..:...|      ..:..||..:..|.:|.:|..|:.||.|:.  ..|:.:| .|
Human   180 D-IRKKAAIQTFQNTYQ------VLAVTFNDTSDQIISGGIDNDIKVWDLRQN--KLTYTMR-GH 234

  Fly   377 QKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFS------RYDTTDCCFSPD 435
              ...:|.:..|..|..|.:.:.|.|:::||:|.| .|......:|.      ..:...|.:|||
Human   235 --ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF-APKERCVKIFQGNVHNFEKNLLRCSWSPD 296

  Fly   436 DRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLWHP 482
                  |..:..|.|:..:|.:.|.|...:.::|.....:.:..:||
Human   297 ------GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	70/307 (23%)
		WD40	180..497	CDD:295369	70/307 (23%)
		WD40 repeat	185..227	CDD:293791	7/34 (21%)
		WD40 repeat	233..268	CDD:293791	8/34 (24%)
		WD40 repeat	273..329	CDD:293791	15/57 (26%)
		WD40 repeat	337..374	CDD:293791	10/36 (28%)
		WD40 repeat	382..419	CDD:293791	11/36 (31%)
		WD40 repeat	427..469	CDD:293791	10/41 (24%)
		WD40 repeat	475..497	CDD:293791	2/8 (25%)
SNRNP40	NP_004805.2	WD40	62..351	CDD:238121	70/307 (23%)
		WD 1	64..103		9/38 (24%)
		WD40 repeat	70..107	CDD:293791	9/42 (21%)
		WD 2	107..146		8/50 (16%)
		WD40 repeat	112..148	CDD:293791	9/47 (19%)
		WD 3	149..189		12/42 (29%)
		WD40 repeat	155..190	CDD:293791	11/37 (30%)
		WD 4	191..230		11/46 (24%)
		WD40 repeat	196..232	CDD:293791	10/37 (27%)
		WD 5	233..272		12/41 (29%)
		WD40 repeat	238..278	CDD:293791	11/40 (28%)
		WD 6	283..322		10/44 (23%)
		WD40 repeat	288..312	CDD:293791	8/29 (28%)
		WD 7	325..357		2/13 (15%)
		WD40 repeat	330..352	CDD:293791	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910