Protein Alignment CG5543 and WDR46

DIOPT Version :9

• Sequence 1: NP_611832.1
• Gene: CG5543 / 37768
• FlyBaseID: FBgn0034908
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_016866973.1
• Gene: WDR46 / 9277
• HGNCID: 13923
• Length: 754
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 128/679 - (18%)
• Similarity: 219/679 - (32%)
• Gaps: 233/679 - (34%)

  Fly    92 IEKARVT-RPGMDKK-REESKPKEDDQKDEEEEDVIGPLP-PAVTTDKEKATKESSKDEDSDDDD 153
            ::|:|:: :|.:.|| ||...|:........::...||.| |.....|.....:|.|...|....
Human    64 LKKSRISKKPQVPKKPREWKNPESQRGLSGTQDPFPGPAPVPVEVVQKFCRIDKSRKLPHSKAKT 128

  Fly   154 YSSDE--DSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFA---- 212
            .|..|  ::::|::..|            .:|:.|.||.:|.......|.....:|..|..
Human   129 RSRLEVAEAEEEETSIK------------AARSELLLAEEPGFLEGEDGEDTAKICQADIVEAVD 181

  Fly   213 ------GMDSSMRSFRQLQPCENHPIRSLQYSVTG------------------------------ 241
                  ..|.::|.|        .|.| |.||.||
Human   182 IASAAKHFDLNLRQF--------GPYR-LNYSRTGRHLAFGGRRGHVAALDWVTKKLMCEINVME 237

  Fly   242 ----------DMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNR 296
                      :.:|.::.|....:.|..|.| |.|.:....::.:.             :.||:
Human   238 AVRDIRFLHSEALLAVAQNRWLHIYDNQGIE-LHCIRRCDRVTRLE-------------FLPFH- 287

  Fly   297 EQFLTAALDGTLRIWQGLKSKEQLQVIK----TRAQGGLRTNAASCN-FNRDATLIAAGCVDGSI 356
              ||.|....|     |..:...:.|.|    ..|:.| |.:..|.| :|   .:|..|..:|::
Human   288 --FLLATASET-----GFLTYLDVSVGKIVAALNARAG-RLDVMSQNPYN---AVIHLGHSNGTV 341

  Fly   357 QTWD-TRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTN 420
            ..|. ..|..:....|    |:.|  :.::.....|..:||...|..:|::|||...|||.|.|
Human   342 SLWSPAMKEPLAKILC----HRGG--VRAVAVDSTGTYMATSGLDHQLKIFDLRGTYQPLSTRT- 399

  Fly   421 LFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLW----- 480
                                    ||.|   |....:|.:.      :.|:....|..:|
Human   400 ------------------------LPHG---AGHLAFSQRG------LLVAGMGDVVNIWAGQGK 431

  Fly   481 --HPKLNQLFVSCGNGTIKCYYDEHR---SIRGAKLCVVKTHRKRQPMEMV-------GVSQIIT 533
              .|.|.|.:::            ||   .:.|.:.|         |.|.|       |::.::.
Human   432 ASPPSLEQPYLT------------HRLSGPVHGLQFC---------PFEDVLGVGHTGGITSMLV 475

  Fly   534 PHA-LPLF-----RQEKSRTSRKRME-KARMDPVKSQ--------RPDLPITSGQGGRVASSGGT 583
            |.| .|.|     ...:||..|:..| ||.::.|.::        ..::.:.|.:.|:...
Human   476 PGAGEPNFDGLESNPYRSRKQRQEWEVKALLEKVPAELICLDPRALAEVDVISLEQGKKEQ---- 536

  Fly   584 LSSYVIRNLGLSKRVDDDQDPR---------EAILKYAKDAAE-----NPYWIAPAYKQTQPKAI 634
                 |..||...:......|:         .:::|..:...:     |.:|..|...|..|..:
Human   537 -----IERLGYDPQAKAPFQPKPKQKGRSSTASLVKRKRKVMDEEHRVNEHWHGPGLPQAAPSCL 596

  Fly   635 --------FSEKLPADEPATKKPKTEADK 655
                    .|..:|...| :..|:|.:.:
Human   597 CLCPCQPATSHSVPVSSP-SPVPRTRSGR 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	76/412 (18%)
		WD40	180..497	CDD:295369	72/379 (19%)
		WD40 repeat	185..227	CDD:293791	10/51 (20%)
		WD40 repeat	233..268	CDD:293791	13/74 (18%)
		WD40 repeat	273..329	CDD:293791	10/59 (17%)
		WD40 repeat	337..374	CDD:293791	9/38 (24%)
		WD40 repeat	382..419	CDD:293791	12/36 (33%)
		WD40 repeat	427..469	CDD:293791	5/41 (12%)
		WD40 repeat	475..497	CDD:293791	5/28 (18%)
WDR46	XP_016866973.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910