DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and CMR1

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_010125.1	Gene:	CMR1 / 851399	SGDID:	S000002315	Length:	522	Species:	Saccharomyces cerevisiae

Alignment Length:	560	Identity:	114/560 - (20%)
Similarity:	206/560 - (36%)	Gaps:	144/560 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FKKMDKEQMIRQIEDVAEDLE----SQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKK 105
            |:|...|. |::..|:.:.|.    :..:|...|:....|..||        :|.:.|.....|.
Yeast     7 FQKKRLEN-IKRNNDLLKKLHLSGVASQIKHEAGVLEKSRAPAK--------KKQKTTNTRATKS 62

  Fly   106 REESKPKEDDQ--KDEEEEDVIGPLPPAVTTDKEKATKESSKDEDSDD-------------DDYS 155
            ...:.|....:  :.|..:||.| :|........|......:|::..|             .|..
Yeast    63 ASPTLPTRRSRRLRGESADDVKG-IPNVNDNQLLKMGSPDGQDKNFIDAIKEKPVIGDVKLSDLI 126

  Fly   156 SDEDSDDEQSLAKRIPYTHEVQMQHGS--RAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSM 218
            .||   ||.:|.::....:......|.  ..:....||      |:|..::|:..:|....:...
Yeast   127 KDE---DESALLEKFKRFNNGNFSSGDFFEEIKKRQGD------VTGMDEFDLDLYDVFQPNEIK 182

  Fly   219 RSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGF-----EKLECCKGDQYIS-DMS 277
            .::.::.....||....:        |:|:|:....|    ||     |.|...:.|:... |::
Yeast   183 ITYERISATYFHPAMEKK--------LIIAGDTSGTV----GFWNVRDEPLADSEEDRMEEPDIT 235

  Fly   278 RTK---GHVAQLTSGCWHPFNREQFLTAALDGTLRI--WQGLKSKEQLQVIKTRAQGGLRTNAAS 337
            |.|   .:|.::  .|: |.:..:.|..:.||::|.  ...|:|:|.| .:|......|  ..:.
Yeast   236 RVKLFTKNVGRI--DCF-PADTSKILLTSYDGSIRSVHLNNLQSEEVL-TLKNEYDDSL--GISD 294

  Fly   338 CNFN-RDATLIAAGCVDGSIQTWDTR--KMFVNTTHCVRDAHQK-GSEITSIVFSYMGQQLATRS 398
            |.|: .:..::....:.|...|:|||  |...|..   |.|.:| ||...:.:..|   ::||.|
Yeast   295 CQFSYENPNVLFLTTLGGEFTTFDTRVKKSEYNLR---RLADKKIGSMAINPMRPY---EIATGS 353

  Fly   399 NDETMKLWDLRQF-KQPLHTWT--------NLFSRYDT----TDCCFSPDDRLLV---------- 440
            .|.|:|:||.|.. |:|  .|:        .:.|.||:    :...:||.|..||
Yeast   354 LDRTLKIWDTRNLVKKP--EWSQYEDYPSHEIVSTYDSRLSVSAVSYSPTDGTLVCNGYDDTIRL 416

  Fly   441 ------------------------TGE--SLPKGQAEAN------------LYFYSTKSYEEVQR 467
                                    ||.  |:.|.:.:.|            :..|:::. :::..
Yeast   417 FDVKSRDHLSAKLEPKLTIQHNCQTGRWTSILKARFKPNKNVFAIANMKRAIDIYNSEG-QQLAH 480

  Fly   468 IPVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIR 507
            :|.:....|.: |||..|.:.....:|.|..:.|:..:|:
Yeast   481 LPTATVPAVIS-WHPLRNWIAGGNSSGKIFLFTDDSGTIK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	85/414 (21%)
		WD40	180..497	CDD:295369	82/394 (21%)
		WD40 repeat	185..227	CDD:293791	6/41 (15%)
		WD40 repeat	233..268	CDD:293791	8/39 (21%)
		WD40 repeat	273..329	CDD:293791	15/61 (25%)
		WD40 repeat	337..374	CDD:293791	9/39 (23%)
		WD40 repeat	382..419	CDD:293791	12/37 (32%)
		WD40 repeat	427..469	CDD:293791	11/93 (12%)
		WD40 repeat	475..497	CDD:293791	6/21 (29%)
CMR1	NP_010125.1	WD40	234..521	CDD:421866	66/302 (22%)
		WD40 repeat	244..281	CDD:293791	11/40 (28%)
		WD40 repeat	293..329	CDD:293791	9/35 (26%)
		WD40 repeat	336..376	CDD:293791	15/44 (34%)
		WD40 repeat	393..436	CDD:293791	5/42 (12%)
		WD40 repeat	447..478	CDD:293791	3/31 (10%)
		WD40 repeat	486..513	CDD:293791	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910