DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and DRS1

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_178186.1	Gene:	DRS1 / 844410	AraportID:	AT1G80710	Length:	516	Species:	Arabidopsis thaliana

Alignment Length:	445	Identity:	106/445 - (23%)
Similarity:	162/445 - (36%)	Gaps:	119/445 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 KDEEEEDVIGPLPPAVTTDKEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHG 181
            |||.|.      |...|....:.:|.|.|.|:.:||.:|  :..:.|.|:..: |...|..:.
plant   147 KDENES------PMVRTRSSSRVSKVSVKKEEPEDDSFS--DYVNKEFSIPVK-PEKIEFDLD-- 200

  Fly   182 SRAVLALAGDPSG-ARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMIL 245
               :|.|  :|.. ||:|.|.|                 ...|..||||     ::....||.:
plant   201 ---LLTL--EPQNVARVVPGRI-----------------FVVQFLPCEN-----VKMVAAGDKL- 237

  Fly   246 VISGNAQAKVLDRDGFEKLECCKGDQYISD-MSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLR 309
               ||.        ||..|:|  |::..:| :.....|.|.::|..:...:..:.::::.||.:|
plant   238 ---GNV--------GFWNLDC--GNEEDNDGIYLFTPHSAPVSSIVFQQNSLSRVISSSYDGLIR 289

  Fly   310 IWQGLKSKEQL-----QVIKTRAQGGLRTN-AASCNFNRDATLIAAGCVDGSIQTWDTR---KMF 365
            :....||...|     :.|.:.:|   |.| ..|..|.:|.         |....||.|   .:|
plant   290 LMDVEKSVFDLVYSTDEAIFSLSQ---RPNDEQSLYFGQDY---------GVFNVWDLRAGKSVF 342

  Fly   366 VNTTHCVRDAHQKGSEITSIVFSYMGQQ-LATRSNDETMKLWDLRQF--KQPLHTWTNLFSRYDT 427
                |.  :.|::  .|.||.|:..... :||.|.|.|..|||||..  |:|....|...|| ..
plant   343 ----HW--ELHER--RINSIDFNPQNPHVMATSSTDGTACLWDLRSMGAKKPKTLSTVNHSR-AV 398

  Fly   428 TDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLWHPKLNQL----- 487
            ....|||      :|.||.....:..:...|..::|....|..:|.    :.|..|...:
plant   399 HSAYFSP------SGLSLATTSLDNYIGVLSGANFENTCMIYHNNT----SRWISKFKAVWGWDD 453

  Fly   488 -FVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMVGVSQIITP---HALP 538
             ::..||             ...|:.|:....||..||:....|...|   |..|
plant   454 SYIYVGN-------------LSKKIDVINPKLKRTVMELHNPLQRAIPCRIHCHP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	82/366 (22%)
		WD40	180..497	CDD:295369	79/336 (24%)
		WD40 repeat	185..227	CDD:293791	9/42 (21%)
		WD40 repeat	233..268	CDD:293791	8/34 (24%)
		WD40 repeat	273..329	CDD:293791	11/61 (18%)
		WD40 repeat	337..374	CDD:293791	9/39 (23%)
		WD40 repeat	382..419	CDD:293791	16/39 (41%)
		WD40 repeat	427..469	CDD:293791	8/41 (20%)
		WD40 repeat	475..497	CDD:293791	4/27 (15%)
DRS1	NP_178186.1	WD40	214..513	CDD:392136	83/362 (23%)
		WD40 repeat	220..261	CDD:293791	15/59 (25%)
		WD40 repeat	266..301	CDD:293791	6/34 (18%)
		WD40 repeat	309..345	CDD:293791	12/53 (23%)
		WD40 repeat	351..390	CDD:293791	16/38 (42%)
		WD40 repeat	398..435	CDD:293791	9/42 (21%)
		WD40 repeat	442..468	CDD:293791	4/38 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910