DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and MAC3A

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001030958.1	Gene:	MAC3A / 839503	AraportID:	AT1G04510	Length:	523	Species:	Arabidopsis thaliana

Alignment Length:	291	Identity:	69/291 - (23%)
Similarity:	111/291 - (38%)	Gaps:	61/291 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 LVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGF 261
            :.:|.||.....:|       ..|.:.|.....|..:.......||..||::.::...|
plant   237 IATGGIDTTAVLFD-------RPSGQILSTLTGHSKKVTSIKFVGDTDLVLTASSDKTV------ 288

  Fly   262 EKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIW--QGLKSKEQLQVIK 324
             ::..|..|...:.....|.|.|::.:...|..|: .|::|:||.|   |  ..|.|...|..:.
plant   289 -RIWGCSEDGNYTSRHTLKDHSAEVRAVTVHATNK-YFVSASLDST---WCFYDLSSGLCLAQVT 348

  Fly   325 TRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSY 389
            ..::..:...||:  |:.|..::..|.....::.||.:    :..:..:.....| |||||.||.
plant   349 DASENDVNYTAAA--FHPDGLILGTGTAQSIVKIWDVK----SQANVAKFGGHNG-EITSISFSE 406

  Fly   390 MGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEAN- 453
            .|..|||.:.| .::|||||:.|.        |..:|..|                      ||
plant   407 NGYFLATAALD-GVRLWDLRKLKN--------FRTFDFPD----------------------ANS 440

  Fly   454 LYFYSTKSYEEV--QRIPVSNAHVVKTLWHP 482
            :.|..:.||..:  ..|.|..|..||..|:|
plant   441 VEFDHSGSYLGIAASDIRVFQAASVKAEWNP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	69/291 (24%)
		WD40	180..497	CDD:295369	69/291 (24%)
		WD40 repeat	185..227	CDD:293791	6/29 (21%)
		WD40 repeat	233..268	CDD:293791	5/34 (15%)
		WD40 repeat	273..329	CDD:293791	14/57 (25%)
		WD40 repeat	337..374	CDD:293791	5/36 (14%)
		WD40 repeat	382..419	CDD:293791	17/36 (47%)
		WD40 repeat	427..469	CDD:293791	6/44 (14%)
		WD40 repeat	475..497	CDD:293791	4/8 (50%)
MAC3A	NP_001030958.1	Ubox	1..65	CDD:128780
		Prp19	67..130	CDD:285771
		WD40	213..>508	CDD:225201	69/291 (24%)
		WD40	224..508	CDD:238121	69/291 (24%)
		WD40 repeat	225..262	CDD:293791	6/31 (19%)
		WD40 repeat	268..307	CDD:293791	7/45 (16%)
		WD40 repeat	312..348	CDD:293791	11/39 (28%)
		WD40 repeat	358..393	CDD:293791	7/40 (18%)
		WD40 repeat	399..434	CDD:293791	18/43 (42%)
		WD40 repeat	439..476	CDD:293791	11/33 (33%)
		WD40 repeat	484..508	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910