DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and AT2G20330

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_179623.1	Gene:	AT2G20330 / 816552	AraportID:	AT2G20330	Length:	648	Species:	Arabidopsis thaliana

Alignment Length:	676	Identity:	249/676 - (36%)
Similarity:	370/676 - (54%)	Gaps:	74/676 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISFGKI-KLNVNVPPAEPRSNETE-AEDAKESTEASGNGGGFKKMDKEQMIRQIEDVAEDLESQH 68
            :||||. |::.:.......:..|: |.||..|::.:     .||.|.:      :.....|.|..
plant    14 VSFGKTSKVSASTEAIHSATRRTDVANDAGVSSDIT-----TKKPDSD------KSGFPSLSSSS 67

  Fly    69 LKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREESKPKEDDQ----------------K 117
            ...:..:.|..|..      |...:.|....|....||.:.:.:||::                .
plant    68 QTWLRSVRGPNRNP------NSSGDVAMGPPPPPSSKRTQEEEEEDEEVMMGPPPPPKGLGNIND 126

  Fly   118 DEEEEDVIGPLPPAVTTDKEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGS 182
            .::|.|:|||.||      ..|.::|  ||||||||     |:|:|:: ..:||.::|:|::..:
plant   127 SDDEGDMIGPPPP------PPAARDS--DEDSDDDD-----DNDNEEN-RYQIPLSNEIQLKGHT 177

  Fly   183 RAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVI 247
            :.|.:||.|.:|||::|||.||.:..:||.||:|.::||||::|.|.|.:||:.:|.|....|.:
plant   178 KIVSSLAVDSAGARVLSGSYDYTVRMYDFQGMNSRLQSFRQIEPSEGHQVRSVSWSPTSGQFLCV 242

  Fly   248 SGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQ 312
            :|:||||:.||||....|..|||.||.|:..||||:..||.|.|||..:|..||::.||:||||.
plant   243 TGSAQAKIFDRDGLTLGEFMKGDMYIRDLKNTKGHICGLTCGEWHPRTKETVLTSSEDGSLRIWD 307

  Fly   313 GLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTR-------KMFVNTTH 370
            ......|.||||.:.....|....:|.::||...||.|..|||||.|..:       .::|...|
plant   308 VNNFLSQTQVIKPKLARPGRVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWGSRPDIYVGKAH 372

  Fly   371 CVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPD 435
            .        .:|||:.||..|:.|.:||.|.::|:|||||.|:.|..:..|.:.|..|:..||||
plant   373 T--------DDITSVKFSSDGRILLSRSFDGSLKVWDLRQMKEALKVFEGLPNYYPQTNVAFSPD 429

  Fly   436 DRLLVTGESLPKGQAEANLY-FYSTKSYEEVQRIPVS-NAHVVKTLWHPKLNQLFVSCGN---GT 495
            :::::||.|:.|......|. ||.....|.||::.:| .:.||:..|||:|||:|.:.|:   |.
plant   430 EQIILTGTSVEKDSTTGGLLCFYDRTKLEIVQKVGISPTSSVVQCAWHPRLNQIFATSGDKSQGG 494

  Fly   496 IKCYYDEHRSIRGAKLCVVKTHRKRQPMEMVGVSQIITPHALPLFRQEKSRTSRKRMEKARMDPV 560
            ....||..:|.|||.:||.:..||:...:......|..||||||||...||  ::..|||..||:
plant   495 THILYDPSQSERGACVCVARAPRKKSVDDYQPEPVIHNPHALPLFRDAPSR--KREREKALKDPM 557

  Fly   561 KSQRPDLPITS-GQGGRVASSG-GTLSSYVIRNLGLSKRVDDDQDPREAILKYAKDAAENPYWIA 623
            ||.:|::|:|. |.||||.::| |.|:.|:::..|:.|....::||||||||||:.|.::|.:||
plant   558 KSHKPEIPMTGPGHGGRVGTTGSGLLTQYLLKQGGMIKETWMEEDPREAILKYAEVAVKDPKFIA 622

  Fly   624 PAYKQTQPKAIFSEKLPADEPA-TKK 648
            |||.|||||.||::....:|.. |||
plant   623 PAYSQTQPKTIFAKSDDEEEEGDTKK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	141/358 (39%)
		WD40	180..497	CDD:295369	131/328 (40%)
		WD40 repeat	185..227	CDD:293791	21/41 (51%)
		WD40 repeat	233..268	CDD:293791	15/34 (44%)
		WD40 repeat	273..329	CDD:293791	26/55 (47%)
		WD40 repeat	337..374	CDD:293791	14/43 (33%)
		WD40 repeat	382..419	CDD:293791	18/36 (50%)
		WD40 repeat	427..469	CDD:293791	15/42 (36%)
		WD40 repeat	475..497	CDD:293791	11/24 (46%)
AT2G20330	NP_179623.1	WD40	172..491	CDD:238121	131/326 (40%)
		WD40 repeat	180..222	CDD:293791	21/41 (51%)
		WD40 repeat	228..273	CDD:293791	21/44 (48%)
		WD40 repeat	278..317	CDD:293791	16/38 (42%)
		WD40 repeat	331..369	CDD:293791	12/37 (32%)
		WD40 repeat	376..413	CDD:293791	18/36 (50%)
		WD40 repeat	421..464	CDD:293791	15/42 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1081
eggNOG	1	0.900	-	-		E1_KOG0772
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9972
Inparanoid	1	1.050	386	1.000	Inparanoid score	I512
OMA	1	1.010	-	-		QHG55687
OrthoDB	1	1.010	-	-		D729650at2759
OrthoFinder	1	1.000	-	-		FOG0005020
OrthoInspector	1	1.000	-	-		oto3667
orthoMCL	1	0.900	-	-		OOG6_102528
Panther	1	1.100	-	-	LDO	PTHR16017
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4081
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840