DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and WDR61

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001290176.1	Gene:	WDR61 / 80349	HGNCID:	30300	Length:	305	Species:	Homo sapiens

Alignment Length:	264	Identity:	51/264 - (19%)
Similarity:	86/264 - (32%)	Gaps:	92/264 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SDDEQSLAKRIPYTH--------------EVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWD 210
            |.|.|.||..   ||              |..:....:.:|::|..|.|..|.||:||..:..:|
Human   115 SPDSQYLATG---THVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176

  Fly   211 FAGMDSSMRSFRQLQPCENH--PIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYI 273
            .|       :.:.|...|.|  |||||.:|....:::..|.:...|:.|            .|:.
Human   177 IA-------TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD------------VQHA 222

  Fly   274 SDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASC 338
            :......||.:                          |.                    .|.|.|
Human   223 NLAGTLSGHAS--------------------------WV--------------------LNVAFC 241

  Fly   339 NFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETM 403
               .|.|...:...|.|::.||     |.|..||........::..:.::..|.::.:..:|:.:
Human   242 ---PDDTHFVSSSSDKSVKVWD-----VGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEI 298

  Fly   404 KLWD 407
            .::|
Human   299 HIYD 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	46/252 (18%)
		WD40	180..497	CDD:295369	43/230 (19%)
		WD40 repeat	185..227	CDD:293791	12/41 (29%)
		WD40 repeat	233..268	CDD:293791	7/34 (21%)
		WD40 repeat	273..329	CDD:293791	3/55 (5%)
		WD40 repeat	337..374	CDD:293791	11/36 (31%)
		WD40 repeat	382..419	CDD:293791	3/26 (12%)
		WD40 repeat	427..469	CDD:293791
		WD40 repeat	475..497	CDD:293791
WDR61	NP_001290176.1	WD40	13..302	CDD:238121	50/262 (19%)
		WD 1	14..57
		WD40 repeat	19..62	CDD:293791
		WD 2	62..101
		WD40 repeat	68..105	CDD:293791
		WD 3	104..143		8/30 (27%)
		WD40 repeat	110..146	CDD:293791	8/33 (24%)
		WD 4	146..187		12/47 (26%)
		WD40 repeat	152..188	CDD:293791	12/42 (29%)
		WD 5	188..227		11/50 (22%)
		WD40 repeat	193..229	CDD:293791	9/47 (19%)
		WD 6	230..269		16/92 (17%)
		WD40 repeat	236..271	CDD:293791	13/42 (31%)
		WD 7	272..305		3/31 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910