DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5543 and Wdr33

DIOPT Version :9

Sequence 1:NP_611832.1 Gene:CG5543 / 37768 FlyBaseID:FBgn0034908 Length:655 Species:Drosophila melanogaster
Sequence 2:XP_006526361.1 Gene:Wdr33 / 74320 MGIID:1921570 Length:1342 Species:Mus musculus


Alignment Length:656 Identity:130/656 - (19%)
Similarity:243/656 - (37%) Gaps:178/656 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 FKKMDKEQMIRQIEDVAEDLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREES 109
            |:.....|:..:..|.|:....|.|               .|| .:::.|| |.|..:|......
Mouse    17 FQHQAPRQLFYKRPDFAQQQAMQQL---------------TFD-GKRMRKA-VNRKTIDYNPSVI 64

  Fly   110 KPKEDD--QKDEEEEDVIGP--------LPP---------AVTTDKEKATKESSKDEDSDDDDYS 155
            |..|:.  |:|:.:...|.|        :||         ||||   |..:.|            
Mouse    65 KYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTT---KFVRTS------------ 114

  Fly   156 SDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRS 220
                             |::|:.     .|..:...|.|.|||:|:...:...|:  |:..   :
Mouse   115 -----------------TNKVKC-----PVFVVRWTPEGRRLVTGASSGEFTLWN--GLTF---N 152

  Fly   221 FRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTK---GH 282
            |..:....:.|:|::.:| ..||.::.:        |..|:.|       .:.|:|:..|   .|
Mouse   153 FETILQAHDSPVRAMTWS-HNDMWMLTA--------DHGGYVK-------YWQSNMNNVKMFQAH 201

  Fly   283 VAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLI 347
            ...:....:.|.: .:|.|.:.|||:|||..|:..|:      |...|...:....:::....|:
Mouse   202 KEAIREASFSPTD-NKFATCSDDGTVRIWDFLRCHEE------RILRGHGADVKCVDWHPTKGLV 259

  Fly   348 AAGCVDGS--IQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQ 410
            .:|..|..  |:.||.:     |...:...|...:.:..:..:..|..|.|.|.|...||:|:|.
Mouse   260 VSGSKDSQQPIKFWDPK-----TGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN 319

  Fly   411 FKQPLHTWTNLFSRYDTTDCCFSP-DDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAH 474
            .|:.|..:..  .:.:.|...:.| .:.|..:|.|      :.:|.|:.....:||..:.:::..
Mouse   320 LKEELQVFRG--HKKEATAVAWHPVHEGLFASGGS------DGSLLFWHVGVEKEVGGMEMAHEG 376

  Fly   475 VVKTL-WHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMV-GVSQ------I 531
            ::.:| ||| |..:..|..|.....::..:|.  |.|:      |.|..:.:: |:|:      .
Mouse   377 MIWSLAWHP-LGHILCSGSNDHTSKFWTRNRP--GDKM------RDRYNLNLLPGMSEDGVEYDD 432

  Fly   532 ITPHALPLF------RQEKSRTSRKRMEKARMDPVKSQRPDLPITSGQGGRVASSGGTLSSYVIR 590
            :.|::|.:.      .|.|....:::|.|.....::...|.|                       
Mouse   433 LEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESSEIEMTIPGL----------------------- 474

  Fly   591 NLGLSKRVDDDQD--PREAILKYAKDAAENPYWIAPAYKQTQ-----PKAIFSEKLPADEPATKK 648
            :.|:.:.:..||.  |::.: .|||..   |.....|:.|.:     |..:.::: ..|....:|
Mouse   475 DWGMEEVMQKDQKKVPQKKV-PYAKPI---PAQFQQAWMQNKVPIPAPNEVLNDR-KEDIKLEEK 534

  Fly   649 PKTEAD 654
            .||:|:
Mouse   535 KKTQAE 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5543NP_611832.1 WD40 <172..519 CDD:225201 75/353 (21%)
WD40 180..497 CDD:295369 70/323 (22%)
WD40 repeat 185..227 CDD:293791 10/41 (24%)
WD40 repeat 233..268 CDD:293791 7/34 (21%)
WD40 repeat 273..329 CDD:293791 16/58 (28%)
WD40 repeat 337..374 CDD:293791 7/38 (18%)
WD40 repeat 382..419 CDD:293791 11/36 (31%)
WD40 repeat 427..469 CDD:293791 9/42 (21%)
WD40 repeat 475..497 CDD:293791 7/22 (32%)
Wdr33XP_006526361.1 WD40 121..402 CDD:238121 70/322 (22%)
WD40 repeat 122..159 CDD:293791 10/41 (24%)
WD40 repeat 165..200 CDD:293791 10/50 (20%)
WD40 repeat 205..241 CDD:293791 12/42 (29%)
WD40 repeat 248..285 CDD:293791 7/41 (17%)
WD40 repeat 291..328 CDD:293791 11/36 (31%)
WD40 repeat 336..371 CDD:293791 8/40 (20%)
WD40 repeat 378..402 CDD:293791 7/24 (29%)
DUF2076 537..>640 CDD:391571 2/4 (50%)
Med15 <590..>926 CDD:312941
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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