DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and WDR33

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_060853.3	Gene:	WDR33 / 55339	HGNCID:	25651	Length:	1336	Species:	Homo sapiens

Alignment Length:	656	Identity:	130/656 - (19%)
Similarity:	244/656 - (37%)	Gaps:	178/656 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FKKMDKEQMIRQIEDVAEDLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREES 109
            |:.....|:..:..|.|:....|.|               .|| .:::.|| |.|..:|......
Human    17 FQHQAPRQLFYKRPDFAQQQAMQQL---------------TFD-GKRMRKA-VNRKTIDYNPSVI 64

  Fly   110 KPKEDD--QKDEEEEDVIGP--------LPP---------AVTTDKEKATKESSKDEDSDDDDYS 155
            |..|:.  |:|:.:...|.|        :||         ||||   |..:.|
Human    65 KYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTT---KFVRTS------------ 114

  Fly   156 SDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRS 220
                             |::|:.     .|..:...|.|.|||:|:...:...|:  |:..   :
Human   115 -----------------TNKVKC-----PVFVVRWTPEGRRLVTGASSGEFTLWN--GLTF---N 152

  Fly   221 FRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTK---GH 282
            |..:....:.|:|::.:| ..||.::.:        |..|:.|       .:.|:|:..|   .|
Human   153 FETILQAHDSPVRAMTWS-HNDMWMLTA--------DHGGYVK-------YWQSNMNNVKMFQAH 201

  Fly   283 VAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLI 347
            ...:....:.|.: .:|.|.:.|||:|||..|:..|:      |...|...:....:::....|:
Human   202 KEAIREASFSPTD-NKFATCSDDGTVRIWDFLRCHEE------RILRGHGADVKCVDWHPTKGLV 259

  Fly   348 AAGCVDGS--IQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQ 410
            .:|..|..  |:.||.:     |...:...|...:.:..:..:..|..|.|.|.|...||:|:|.
Human   260 VSGSKDSQQPIKFWDPK-----TGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN 319

  Fly   411 FKQPLHTWTNLFSRYDTTDCCFSP-DDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAH 474
            .|:.|..:..  .:.:.|...:.| .:.|..:|.|      :.:|.|:.....:||..:.:::..
Human   320 LKEELQVFRG--HKKEATAVAWHPVHEGLFASGGS------DGSLLFWHVGVEKEVGGMEMAHEG 376

  Fly   475 VVKTL-WHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMV-GVSQ------I 531
            ::.:| ||| |..:..|..|.....::..:|.  |.|:      |.|..:.:: |:|:      .
Human   377 MIWSLAWHP-LGHILCSGSNDHTSKFWTRNRP--GDKM------RDRYNLNLLPGMSEDGVEYDD 432

  Fly   532 ITPHALPLF------RQEKSRTSRKRMEKARMDPVKSQRPDLPITSGQGGRVASSGGTLSSYVIR 590
            :.|::|.:.      .|.|....:::|.|...:.::...|.|
Human   433 LEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGL----------------------- 474

  Fly   591 NLGLSKRVDDDQD--PREAILKYAKDAAENPYWIAPAYKQTQ-----PKAIFSEKLPADEPATKK 648
            :.|:.:.:..||.  |::.: .|||..   |.....|:.|.:     |..:.::: ..|....:|
Human   475 DWGMEEVMQKDQKKVPQKKV-PYAKPI---PAQFQQAWMQNKVPIPAPNEVLNDR-KEDIKLEEK 534

  Fly   649 PKTEAD 654
            .||:|:
Human   535 KKTQAE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	75/353 (21%)
		WD40	180..497	CDD:295369	70/323 (22%)
		WD40 repeat	185..227	CDD:293791	10/41 (24%)
		WD40 repeat	233..268	CDD:293791	7/34 (21%)
		WD40 repeat	273..329	CDD:293791	16/58 (28%)
		WD40 repeat	337..374	CDD:293791	7/38 (18%)
		WD40 repeat	382..419	CDD:293791	11/36 (31%)
		WD40 repeat	427..469	CDD:293791	9/42 (21%)
		WD40 repeat	475..497	CDD:293791	7/22 (32%)
WDR33	NP_060853.3	WD 1	117..156		11/48 (23%)
		WD40	121..>405	CDD:225201	70/325 (22%)
		WD40	121..402	CDD:238121	70/322 (22%)
		WD40 repeat	122..159	CDD:293791	10/41 (24%)
		WD 2	159..198		11/54 (20%)
		WD40 repeat	165..200	CDD:293791	10/50 (20%)
		WD 3	200..239		12/45 (27%)
		WD40 repeat	205..241	CDD:293791	12/42 (29%)
		WD 4	242..283		8/45 (18%)
		WD40 repeat	248..285	CDD:293791	7/41 (17%)
		WD 5	286..325		10/38 (26%)
		WD40 repeat	291..328	CDD:293791	11/36 (31%)
		WD 6	329..369		9/47 (19%)
		WD40 repeat	336..371	CDD:293791	8/40 (20%)
		WD 7	373..412		10/47 (21%)
		WD40 repeat	378..402	CDD:293791	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..1336
		Med15	594..>989	CDD:255446
		Collagen	730..791	CDD:189968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910