DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5543 and WDR70

DIOPT Version :9

Sequence 1:NP_611832.1 Gene:CG5543 / 37768 FlyBaseID:FBgn0034908 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_060504.1 Gene:WDR70 / 55100 HGNCID:25495 Length:654 Species:Homo sapiens


Alignment Length:651 Identity:283/651 - (43%)
Similarity:407/651 - (62%) Gaps:82/651 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 LKEVMGISGFGRKAAKVFDIN---EQ-----IEKARVTRPGMDKKREESKPKE------------ 113
            |...||.:|||:| |:.||:.   ||     :|::|.|....:|:.|.::.||            
Human    21 LAVTMGFTGFGKK-ARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTS 84

  Fly   114 -------------------------DDQKDEE------------------EEDVIGPLPPAVTTD 135
                                     .|..|:|                  |||::|||||.:..:
Human    85 SRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEE 149

  Fly   136 KEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSG 200
            :|:|.:|              :|:.::|::...:||.:||:.::||::.|.||..||||||||:|
Human   150 EEEAEEE--------------EEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTG 200

  Fly   201 SIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLE 265
            ..|||:.||||||||:|.::||.|||||.|.|:|||||.|||||||:||::||||:||||||.:|
Human   201 GYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVME 265

  Fly   266 CCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGG 330
            |.||||||.||:.||||.|.|.:|.|||..:.:|:|.:.|.|:|.|:....|:|..|.|.|...|
Human   266 CIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQG 330

  Fly   331 LRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLA 395
            .:....:|.::||..||||.|.:||||.|| |.:.|:.....:.||..|::.:.:.|||.|..||
Human   331 KKVIPTTCTYSRDGNLIAAACQNGSIQIWD-RNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLA 394

  Fly   396 TRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTK 460
            :|..|:::||||:|||.:||.:.:.|.:.:..|||||||||:|:|||.|:.:|.....|.|:..:
Human   395 SRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERR 459

  Fly   461 SYEEVQRIPVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEM 525
            :::.|..|.:::|.||:.||||||||:.|..|||..|.|||.::|.||||||||||.||.:..|.
Human   460 TFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAET 524

  Fly   526 VGVSQIITPHALPLFRQEKSRTSRKRMEKARMDPVKSQRPDLPITS-GQGGRVASSGGTLSSYVI 589
            :....||||||||:||:.:.|::||::||.|:||:||.:|:.|:.. |:||||.:.|||||||::
Human   525 LTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIV 589

  Fly   590 RNLGLSKRVDDDQDPREAILKYAKDAAENPYWIAPAYKQTQPKAIFSEKLPADEPATKKPKTEAD 654
            :|:.|.|  .||.:||||||::||.|.::|||::|||.:||||.:|::....||.|..:|:.:..
Human   590 KNIALDK--TDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKR 652

  Fly   655 K 655
            |
Human   653 K 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5543NP_611832.1 WD40 <172..519 CDD:225201 179/346 (52%)
WD40 180..497 CDD:295369 162/316 (51%)
WD40 repeat 185..227 CDD:293791 28/41 (68%)
WD40 repeat 233..268 CDD:293791 26/34 (76%)
WD40 repeat 273..329 CDD:293791 24/55 (44%)
WD40 repeat 337..374 CDD:293791 16/36 (44%)
WD40 repeat 382..419 CDD:293791 17/36 (47%)
WD40 repeat 427..469 CDD:293791 18/41 (44%)
WD40 repeat 475..497 CDD:293791 14/21 (67%)
WDR70NP_060504.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 43..175 27/145 (19%)
WD40 165..>492 CDD:225201 163/327 (50%)
WD40 177..498 CDD:295369 163/321 (51%)
WD 1 180..219 26/38 (68%)
WD40 repeat 185..227 CDD:293791 28/41 (68%)
WD 2 227..268 30/40 (75%)
WD40 repeat 233..281 CDD:293791 35/47 (74%)
WD 3 281..321 16/39 (41%)
WD40 repeat 286..324 CDD:293791 14/37 (38%)
WD 4 330..369 17/39 (44%)
WD40 repeat 336..376 CDD:293791 17/40 (43%)
WD 5 376..415 17/38 (45%)
WD40 repeat 382..418 CDD:293791 17/35 (49%)
WD 6 421..466 18/44 (41%)
WD40 repeat 426..470 CDD:293791 19/43 (44%)
WD 7 469..508 21/38 (55%)
WD40 repeat 474..498 CDD:293791 15/23 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..579 18/38 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..654 7/24 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144331
Domainoid 1 1.000 263 1.000 Domainoid score I1941
eggNOG 1 0.900 - - E1_KOG0772
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9972
Inparanoid 1 1.050 554 1.000 Inparanoid score I1120
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55687
OrthoDB 1 1.010 - - D177718at33208
OrthoFinder 1 1.000 - - FOG0005020
OrthoInspector 1 1.000 - - oto91361
orthoMCL 1 0.900 - - OOG6_102528
Panther 1 1.100 - - LDO PTHR16017
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1893
SonicParanoid 1 1.000 - - X4081
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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