DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and wdr33

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001362197.1	Gene:	wdr33 / 548794	XenbaseID:	XB-GENE-6083684	Length:	1598	Species:	Xenopus tropicalis

Alignment Length:	656	Identity:	134/656 - (20%)
Similarity:	246/656 - (37%)	Gaps:	178/656 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FKKMDKEQMIRQIEDVAEDLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREES 109
            |:.....|:..:..|.|:....|.|               .|| .:::.|| |.|..:|......
Frog    17 FQHQAPRQLFYKRPDYAQQQAMQQL---------------TFD-GKRMRKA-VNRKTIDYNPSVI 64

  Fly   110 KPKEDD--QKDEEEEDVIGP--------LPP---------AVTTDKEKATKESSKDEDSDDDDYS 155
            |..|:.  |:|:.:...|.|        :||         ||||   |..:.|
Frog    65 KYLENRVWQRDQRDMRAIQPDAGYYNDLVPPIGMINNPLNAVTT---KFVRTS------------ 114

  Fly   156 SDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRS 220
                             |::|:.     .|..:...|.|.|||:|:...:...|:  |:..   :
Frog   115 -----------------TNKVKC-----PVFVVRWTPEGRRLVTGASSGEFTLWN--GLTF---N 152

  Fly   221 FRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTK---GH 282
            |..:....:.|:|::.:| ..||.::.:        |..|:.|       .:.|:|:..|   .|
Frog   153 FETILQAHDSPVRAMTWS-HNDMWMLTA--------DHSGYVK-------YWQSNMNNVKMFQAH 201

  Fly   283 VAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLI 347
            ...:....:.|.: .:|.|.:.|||:|||..|:..|:      |...|...:....:::....|:
Frog   202 KEAIREASFSPTD-NKFATCSDDGTVRIWDFLRCHEE------RILRGHGADVKCVDWHPTKGLL 259

  Fly   348 AAGCVDGS--IQTWDTRK-MFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLR 409
            .:|..|..  |:.||.:. ..:.|.|    ||:  :.:..:.::..|..|.|.|.|...||:|:|
Frog   260 VSGSKDSQQPIKFWDPKNGQSLATLH----AHK--NTVMEVKWNLNGNWLLTASRDHLCKLFDIR 318

  Fly   410 QFKQPLHTWTNLFSRYDTTDCCFSP-DDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNA 473
            ..::.|..:..  .:.:.|...:.| .:.|..:|.|      :.:|.|:.....:||..:.:::.
Frog   319 NLREELQVFRG--HKKEATAVAWHPVHEGLFASGGS------DGSLLFWHVGVEKEVGGMEIAHE 375

  Fly   474 HVVKTL-WHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMV-GVSQ------ 530
            .::.:| ||| |..:..|..|.....::..:|.  |.|:      |.|..:.:: |:|:
Frog   376 GMIWSLAWHP-LGHILCSGSNDHTSKFWTRNRP--GDKM------RDRYNLNLLPGMSEDGVEYD 431

  Fly   531 IITPHALPLF------RQEKSRTSRKRMEKARMDPVKSQRPDLPITSGQGGRVASSGGTLSSYVI 589
            .|.|:.|.:.      .|.|....:::|.|.....|:...|.|
Frog   432 DIEPNNLAVIPGMGIPEQLKMAMEQEQMSKEESSSVEMTIPGL---------------------- 474

  Fly   590 RNLGLSKRVDDDQD--PREAILKYAKDAAENPYWIAPAYKQTQ-PKAIFSEKLP---ADEPATKK 648
             :.|:.:.:..||.  |::.: .|||..   |.....|:.|.: |....||.:|   .:..:.:|
Frog   475 -DWGMEEVMQKDQKKVPQKKV-PYAKPI---PAQFQQAWMQNKVPLMPPSEAIPDRKEENKSDEK 534

  Fly   649 PKTEAD 654
            .|.:|:
Frog   535 KKNQAE 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	76/354 (21%)
		WD40	180..497	CDD:295369	71/324 (22%)
		WD40 repeat	185..227	CDD:293791	10/41 (24%)
		WD40 repeat	233..268	CDD:293791	7/34 (21%)
		WD40 repeat	273..329	CDD:293791	16/58 (28%)
		WD40 repeat	337..374	CDD:293791	8/39 (21%)
		WD40 repeat	382..419	CDD:293791	10/36 (28%)
		WD40 repeat	427..469	CDD:293791	9/42 (21%)
		WD40 repeat	475..497	CDD:293791	7/22 (32%)
wdr33	NP_001362197.1	WD40	121..402	CDD:238121	71/323 (22%)
		WD40 repeat	122..159	CDD:293791	10/41 (24%)
		WD40 repeat	165..200	CDD:293791	10/50 (20%)
		WD40 repeat	205..241	CDD:293791	12/42 (29%)
		WD40 repeat	248..285	CDD:293791	7/36 (19%)
		WD40 repeat	291..328	CDD:293791	10/36 (28%)
		WD40 repeat	336..372	CDD:293791	8/41 (20%)
		WD40 repeat	378..402	CDD:293791	7/24 (29%)
		PAT1	<479..>646	CDD:370676	16/66 (24%)
		Med15	566..>973	CDD:312941
		Med15	905..>1265	CDD:312941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910