DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and Wdr70

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001074871.1	Gene:	Wdr70 / 545085	MGIID:	1921020	Length:	657	Species:	Mus musculus

Alignment Length:	643	Identity:	285/643 - (44%)
Similarity:	408/643 - (63%)	Gaps:	63/643 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LKEVMGISGFGRKAAKVFDIN---EQ-----IEKARVTRPGMDKKREESKPKE------------ 113
            |...||.:|||:| |:.||:.   ||     :|::|.|....:|:.|.::.||
Mouse    21 LAVTMGFTGFGKK-ARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRKQIEDMEPAP 84

  Fly   114 ------------------------DDQKDEEEEDVIG-PLPPAVTTDKEKATKESS--------- 144
                                    ||..|..::::|| ||||.:..:......|.:
Mouse    85 SSSSAARERSQSSCRDTSSSDSESDDSSDSSDDELIGPPLPPKMVGESVTTVDEGTLGPLPPPLC 149

  Fly   145 -KDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCF 208
             :.||.|||:.   :|..:|.:..:|||.:||:.::||::.|.||..||||||||:|..|||:.|
Mouse   150 EEGEDDDDDEL---DDEGEEDNPVQRIPDSHEITLRHGTKTVSALGLDPSGARLVTGGYDYDVKF 211

  Fly   209 WDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYI 273
            |||||||:|.::||.|||||.|.|:|||||.|||||||:||::||||:||||||.:||.||||||
Mouse   212 WDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYI 276

  Fly   274 SDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASC 338
            .||:.||||.|.|.:|.|||..:.:|:|.:.|.|:|:|:....|:|..|.|.|...|.:....:|
Mouse   277 VDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRLWEVENPKKQKSVFKPRTMQGKKVIPTTC 341

  Fly   339 NFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETM 403
            .::||..|:||.|.:||||.|| |.:.|:.....:.||..|::.:.:.|||.|..||:|..|:|:
Mouse   342 TYSRDGNLVAAACQNGSIQIWD-RNLTVHPKFHYKQAHDPGTDTSCVAFSYDGNVLASRGGDDTL 405

  Fly   404 KLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRI 468
            ||||:|||.:||.:.::|.:.:..|||||||||:|:|||.|:.:|.....|.|...::::.|..|
Mouse   406 KLWDVRQFNKPLFSASDLPTLFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFLERRTFQRVYEI 470

  Fly   469 PVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMVGVSQIIT 533
            .:::|.||:.||||||||:.|..|||..|.|||.::|.||||||||||.||.:..|.:....|||
Mouse   471 HITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIIT 535

  Fly   534 PHALPLFRQEKSRTSRKRMEKARMDPVKSQRPDLPITS-GQGGRVASSGGTLSSYVIRNLGLSKR 597
            |||||:||:.:.|::||::||.|:||:||.:|:.|:.. |:||||.:.|||||||:::|:.|.|
Mouse   536 PHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDK- 599

  Fly   598 VDDDQDPREAILKYAKDAAENPYWIAPAYKQTQPKAIFSEKLPADEPATKKPKTEADK 655
             .||.:||||||::||.|.:||||::|||.:||||.:|::....||.:..:|:.:..|
Mouse   600 -TDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEESKNEPEWKKRK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	179/346 (52%)
		WD40	180..497	CDD:295369	162/316 (51%)
		WD40 repeat	185..227	CDD:293791	28/41 (68%)
		WD40 repeat	233..268	CDD:293791	26/34 (76%)
		WD40 repeat	273..329	CDD:293791	24/55 (44%)
		WD40 repeat	337..374	CDD:293791	15/36 (42%)
		WD40 repeat	382..419	CDD:293791	18/36 (50%)
		WD40 repeat	427..469	CDD:293791	18/41 (44%)
		WD40 repeat	475..497	CDD:293791	14/21 (67%)
Wdr70	NP_001074871.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		285/643 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..172		26/131 (20%)
		WD40	180..501	CDD:421866	163/321 (51%)
		WD 1	183..222		26/38 (68%)
		WD40 repeat	188..230	CDD:293791	28/41 (68%)
		WD 2	230..271		30/40 (75%)
		WD40 repeat	236..284	CDD:293791	35/47 (74%)
		WD 3	284..324		16/39 (41%)
		WD40 repeat	289..327	CDD:293791	14/37 (38%)
		WD 4	333..372		16/39 (41%)
		WD40 repeat	339..373	CDD:293791	15/34 (44%)
		WD 5	379..418		18/38 (47%)
		WD40 repeat	380..421	CDD:293791	19/40 (48%)
		WD 6	424..469		18/44 (41%)
		WD40 repeat	429..470	CDD:293791	18/40 (45%)
		WD 7	472..511		21/38 (55%)
		WD40 repeat	477..501	CDD:293791	15/23 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..584		18/40 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..657		5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834473
Domainoid	1	1.000	261	1.000	Domainoid score	I1951
eggNOG	1	0.900	-	-		E1_KOG0772
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9972
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1106
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55687
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005020
OrthoInspector	1	1.000	-	-		oto94941
orthoMCL	1	0.900	-	-		OOG6_102528
Panther	1	1.100	-	-	LDO	PTHR16017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1893
SonicParanoid	1	1.000	-	-		X4081
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790