DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and CG10931

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	71/343 - (20%)
Similarity:	141/343 - (41%)	Gaps:	51/343 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPC 227
            |.|::......|.: :.| |..|..|....:|..|||.|.|..:..||       :.:.|.:|..
  Fly    39 ENSMSPGYAIKHSL-LGH-SGCVTGLKFSSNGENLVSSSGDRLLKLWD-------LSATRCIQSL 94

  Fly   228 ENH--PIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGC 290
            ..|  .:..:.:|..|   |:.|.:....|...|...|| |.|         ..:||.....|.|
  Fly    95 AGHGDGVNDVAWSAAG---LIASCSDDMTVRLWDARSKL-CVK---------VLEGHSRYSFSCC 146

  Fly   291 WHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGS 355
            ::| ......:.:.|.|:|:|. :::.:.|:::...     :....|.:|:||..:......||.
  Fly   147 FNP-QANLLASTSFDETVRLWD-VRTGKTLKIVHAH-----QDPITSVDFHRDGNIFVTSSYDGL 204

  Fly   356 IQTWDTRKMFVNTTHCVRD-AHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQP--LHT 417
            ::.||:     :|.|.::. .......:..:.||..|:.:.:.:.:.|::||:   :|:|  :.|
  Fly   205 VRLWDS-----STGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWN---YKKPKCMRT 261

  Fly   418 WTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLWHP 482
            :....:.:..::..||....:.:.     .|..:..|..::.::.|.||:|......::.|..||
  Fly   262 YRGHLNEFYCSNSNFSTTGGIWIV-----SGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHP 321

  Fly   483 KLNQLFVSCGNGTIKCYY 500
            ..|.:    .:|.::..|
  Fly   322 TANVI----ASGALQNSY 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	69/334 (21%)
		WD40	180..497	CDD:295369	67/321 (21%)
		WD40 repeat	185..227	CDD:293791	12/41 (29%)
		WD40 repeat	233..268	CDD:293791	9/34 (26%)
		WD40 repeat	273..329	CDD:293791	10/55 (18%)
		WD40 repeat	337..374	CDD:293791	10/36 (28%)
		WD40 repeat	382..419	CDD:293791	9/38 (24%)
		WD40 repeat	427..469	CDD:293791	7/41 (17%)
		WD40 repeat	475..497	CDD:293791	5/21 (24%)
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	69/334 (21%)
		WD40	49..341	CDD:238121	69/333 (21%)
		WD40 repeat	59..96	CDD:293791	12/43 (28%)
		WD40 repeat	102..137	CDD:293791	10/47 (21%)
		WD40 repeat	142..178	CDD:293791	8/37 (22%)
		WD40 repeat	185..220	CDD:293791	10/39 (26%)
		WD40 repeat	227..263	CDD:293791	9/38 (24%)
		WD40 repeat	271..309	CDD:293791	8/42 (19%)
		WD40 repeat	314..340	CDD:293791	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910