DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and Wdr76

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_006234936.1	Gene:	Wdr76 / 311361	RGDID:	1309616	Length:	687	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	108/578 - (18%)
Similarity:	188/578 - (32%)	Gaps:	170/578 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SFGKIKLNVNVPPAEPRSNETEAEDAKESTEASGNGGGFKKMDKEQMIRQIEDVAEDLESQHLKE 71
            |....||.:......|..|::.:|..::.|:.       ||..:..:..:::.::...||..||.
  Rat   122 SLSNPKLGLFKLSKSPVENKSSSEMVQKKTDQ-------KKTCRRVLTSKMKALSSKAESCLLKP 179

  Fly    72 VM---------------------------------------GISGFGRKAAKVFDINE------- 90
            .:                                       |:|.:.||..|  :|.|
  Rat   180 ALDSHTESSELEHKSISDPVTPSVDMESSDEDSAPGPDDFSGLSPYERKRMK--NIRENANFFAS 242

  Fly    91 -QIEKARVTRPGMDKKRE--ESKPKEDDQKDEE----------EEDVIGPLPPAVTTDKEKATKE 142
             |:.::.....||.||.:  |||.|...:|:.|          :.|.:|...||..|......:|
  Rat   243 LQLAESAARLRGMIKKNQPPESKRKRPKKKENEVGCRRSMRLLKVDPLGVSLPASLTQPTLVEEE 307

  Fly   143 SSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMC 207
            :........:  ...|:.||...|.|            .|....|.....|..:...|.......
  Rat   308 TPMIPPGPLE--MIPENQDDCSELFK------------ASLKTWAEMSQTSNEKTKKGLSSIKSY 358

  Fly   208 FWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKV-------LDRDGFEKLE 265
            ....:||..|..:.|::   ....|.|:....:|...||.:|:...:|       ...||  ...
  Rat   359 KASLSGMVVSEATIRKV---TKGAISSVAIHPSGVRTLVAAGSKSGQVGLWDLTQQSEDG--AYA 418

  Fly   266 CCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLR-------IWQGLKSKEQLQVI 323
            .|...|.:|.:|             :.|.|....|:.:.|||:|       :::.:...|
  Rat   419 FCPHSQPVSCLS-------------FSPTNPAHLLSLSYDGTVRCGDFSTAVFEEVYRNE----- 465

  Fly   324 KTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTR------KMFVNTTHCVRDAHQKGSEI 382
                    |.:.:|.:|..||:.:..|...|.:...|.|      :.|:|::.         .:|
  Rat   466 --------RNSLSSFDFLDDASTLLVGHWSGHLSLVDRRTPGTSYEKFINSSL---------EKI 513

  Fly   383 TSIVFSYMGQQLATRSNDETMKLWDLRQFK----QPLHTWT----NLFSRYDTTDCCFSPDDRLL 439
            .::....:.:|....:....:.::|:|..|    |||.:.|    ::.|.|      |||
  Rat   514 RTVHVHPLSRQYFITAGLRDVHVYDVRCLKSGKSQPLISLTEHSKSIASAY------FSP----- 567

  Fly   440 VTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKT---------LWHPKLNQLF 488
            |||..:....|:..|..:.:.|......:..:..|...|         :|.||....|
  Rat   568 VTGNRVVTTCADCKLRVFDSSSLSSQFPLVSTIRHNTITGRWLTRFQAVWDPKQEDCF 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	66/354 (19%)
		WD40	180..497	CDD:295369	66/346 (19%)
		WD40 repeat	185..227	CDD:293791	7/41 (17%)
		WD40 repeat	233..268	CDD:293791	8/41 (20%)
		WD40 repeat	273..329	CDD:293791	10/62 (16%)
		WD40 repeat	337..374	CDD:293791	10/42 (24%)
		WD40 repeat	382..419	CDD:293791	8/40 (20%)
		WD40 repeat	427..469	CDD:293791	9/41 (22%)
		WD40 repeat	475..497	CDD:293791	5/23 (22%)
Wdr76	XP_006234936.1	WD40	<377..659	CDD:225201	58/297 (20%)
		WD40	<377..586	CDD:295369	51/256 (20%)
		WD40 repeat	381..421	CDD:293791	8/41 (20%)
		WD40 repeat	426..459	CDD:293791	9/45 (20%)
		WD40 repeat	467..506	CDD:293791	8/38 (21%)
		WD40 repeat	513..552	CDD:293791	8/38 (21%)
		WD40 repeat	560..606	CDD:293791	12/56 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910