DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and Ercc8

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_017446310.1	Gene:	Ercc8 / 310071	RGDID:	1311570	Length:	404	Species:	Rattus norvegicus

Alignment Length:	253	Identity:	52/253 - (20%)
Similarity:	92/253 - (36%)	Gaps:	76/253 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 LQPCENHPIRSLQYSVTG--DMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKG--HVA 284
            ::|.|.      :|.::|  |.::|:..      |:....:....||.   :..:.|:..  |..
  Rat    51 IEPVEG------RYMLSGGSDGVIVLYD------LENASRQPYYTCKA---VCSVGRSHPDVHKY 100

  Fly   285 QLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDAT---- 345
            .:.:..|:|.:...|.:::.|.||::|.                  ..|..|:..||.:.|
  Rat   101 SVETVQWYPHDTGMFTSSSFDKTLKVWD------------------TNTLQAADVFNFEETVYSH 147

  Fly   346 ----------LIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFS----YMGQQLAT 396
                      |:|.|.....:|..|.:.  .:.:|.::...|   ||.::.:|    |:   |||
  Rat   148 HMSPAATKHCLVAVGTRGPKVQLCDLKS--GSCSHILQGHRQ---EILAVSWSPRYDYI---LAT 204

  Fly   397 RSNDETMKLWDLRQFKQPLHTW-------------TNLFSRYDTTDCCFSPDDRLLVT 441
            .|.|..:||||:|:....|.|.             .|..........||:.|...|:|
  Rat   205 ASADSRVKLWDVRRASGCLLTLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLT 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	52/253 (21%)
		WD40	180..497	CDD:295369	52/253 (21%)
		WD40 repeat	185..227	CDD:293791	0/2 (0%)
		WD40 repeat	233..268	CDD:293791	5/36 (14%)
		WD40 repeat	273..329	CDD:293791	9/57 (16%)
		WD40 repeat	337..374	CDD:293791	9/50 (18%)
		WD40 repeat	382..419	CDD:293791	15/53 (28%)
		WD40 repeat	427..469	CDD:293791	5/15 (33%)
		WD40 repeat	475..497	CDD:293791
Ercc8	XP_017446310.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910