DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and gad-1

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_504635.1	Gene:	gad-1 / 179027	WormBaseID:	WBGene00001513	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	616	Identity:	218/616 - (35%)
Similarity:	330/616 - (53%)	Gaps:	52/616 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 KAAKVFDINEQIEKARVTRPGMDKKREESKPKEDDQKDE----------EEEDVIGPLPPAVTTD 135
            |.|:|||:.....:.....|..::.....:......|.|          :|:|.:..|||.....
Worm    13 KKARVFDLQAMFAQTISNAPRTEEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDLPPGFQMQ 77

  Fly   136 KEKATKESSK---DEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARL 197
            :.:|...||:   .|||||.|:    |..:..|:.|.||...|.::.||::|:.||..:|.|.|.
Worm    78 QSEAGPSSSRAEGPEDSDDSDF----DETEAISIIKLIPAACEAKISHGTQAISALRVEPPGVRF 138

  Fly   198 VSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFE 262
            .||.:||.:..:||..||.|||..::|.|.|:|.|.||.:|..|:.::|.||.|..::|||.|.:
Worm   139 ASGGLDYYVKLFDFQKMDMSMRYDKELLPAESHVINSLAFSPNGETLVVASGEAIIRLLDRAGKQ 203

  Fly   263 KLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSK-------EQL 320
            ..|..:|||||.|::.||||.|.:....::|.|:.:|::.:.||:||:|.....|       :..
Worm   204 WSETVRGDQYIIDLNITKGHTATVNCVEFNPLNKNEFISCSDDGSLRLWNLDDHKVITKCINKHR 268

  Fly   321 QVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSI 385
            :||||:...|.|.:...|.|:.|...|||||.|||:|.|.....:||..:.||.|| .|| ||||
Worm   269 KVIKTKGANGKRVSPQVCTFSPDGKWIAAGCDDGSVQAWKYGSQYVNVNYLVRKAH-NGS-ITSI 331

  Fly   386 VFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQA 450
            .||...::|.:|..|:|:|:|.|...|:||...|.|.:.:.:|||.|||...::.||.|.|....
Worm   332 AFSPDSKRLLSRGFDDTLKMWSLDNPKEPLLVKTGLENAFKSTDCGFSPRAEVVFTGTSSPNKDT 396

  Fly   451 EANLYFYSTKSYEEVQRI--PVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCV 513
            ...|.|:...:::.|.:|  |..:.|.::  |||:|||:.....:|||..|||:..|.||...||
Worm   397 PGTLQFFDPMTFDLVYKIDYPGISCHRIQ--WHPRLNQIIAGLSDGTIHVYYDQTMSQRGVMSCV 459

  Fly   514 VKTHRKRQPMEMVGVSQIITPHALPLFR------QEKSRTSRK-----RMEKARMDPVKSQRPDL 567
            .|..::.:..|:|....:::|.:|.:|:      :||..|..:     ||:..::.|...:..|:
Worm   460 TKPLKRNRASEVVREDMVLSPLSLEMFQPRGEEGEEKEVTGWRIKKYLRMQDNKLRPEFRKPADM 524

  Fly   568 PIT-SGQGGRVASSGGTLSSYVIRNLGLSKRVD--DDQDPREAILKYAKDAAENPYWIAPAYKQT 629
            ||. ....||||:|||:|.||:.:.:|.::..:  .|.|.|.:|||:||||.|||.:|..||::|
Worm   525 PINGKSANGRVAASGGSLHSYLAKQIGTARNAEFLKDTDVRASILKHAKDAEENPLYIDKAYRKT 589

  Fly   630 QPKAIFSEKL--PAD------EPATKKPKTE 652
            |||.||.|..  |.|      :|..|.|:|:
Worm   590 QPKKIFQETAVEPEDQDDEELQPVFKMPRTK 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	137/355 (39%)
		WD40	180..497	CDD:295369	126/325 (39%)
		WD40 repeat	185..227	CDD:293791	17/41 (41%)
		WD40 repeat	233..268	CDD:293791	13/34 (38%)
		WD40 repeat	273..329	CDD:293791	20/62 (32%)
		WD40 repeat	337..374	CDD:293791	16/36 (44%)
		WD40 repeat	382..419	CDD:293791	16/36 (44%)
		WD40 repeat	427..469	CDD:293791	14/43 (33%)
		WD40 repeat	475..497	CDD:293791	8/21 (38%)
gad-1	NP_504635.1	WD40	123..445	CDD:295369	125/325 (38%)
		WD40 repeat	126..168	CDD:293791	17/41 (41%)
		WD40	<139..470	CDD:225201	128/334 (38%)
		WD40 repeat	227..275	CDD:293791	13/47 (28%)
		WD40 repeat	283..321	CDD:293791	15/37 (41%)
		WD40 repeat	328..365	CDD:293791	16/36 (44%)
		WD40 repeat	411..445	CDD:293791	13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158198
Domainoid	1	1.000	152	1.000	Domainoid score	I2650
eggNOG	1	0.900	-	-		E1_KOG0772
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9972
Inparanoid	1	1.050	354	1.000	Inparanoid score	I1320
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55687
OrthoDB	1	1.010	-	-		D177718at33208
OrthoFinder	1	1.000	-	-		FOG0005020
OrthoInspector	1	1.000	-	-		oto18447
orthoMCL	1	0.900	-	-		OOG6_102528
Panther	1	1.100	-	-	LDO	PTHR16017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1893
SonicParanoid	1	1.000	-	-		X4081
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840