DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and pfs-2

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001380152.1	Gene:	pfs-2 / 175092	WormBaseID:	WBGene00011051	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	70/391 - (17%)
Similarity:	147/391 - (37%)	Gaps:	71/391 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 VLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISG 249
            |.::...|.|.||::|....:...|     :.:..:|..:....:..||:|:::.....:|
Worm   136 VYSVCWSPEGKRLITGCQTGEFTLW-----NGTAFNFETILQAHDSAIRALKWASNEQWLL---- 191

  Fly   250 NAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGL 314
                 ..|:.|:.|.    ....:::......|..:...|........:|.||:.|||.|:|...
Worm   192 -----SADQGGYVKY----WQPNMNNAHMFSAHKDEAIRGLAFAPTDVKFATASDDGTARVWDFA 247

  Fly   315 KSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGS--IQTWDTRKMFVNTTHCVRDAHQ 377
            :..|:      |...|........:::....|||.|..|..  ::.||.:     :..|:....:
Worm   248 RYTEE------RVLRGHGAEVRCIDWHPTKGLIATGSRDTQQPVKIWDPK-----SGSCLATLQE 301

  Fly   378 KGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSP-DDRLLVT 441
            ..|.:.::.|:..|..|.|...|..:|::|:|..|: :.|:.  ..:.:.....:.| .:.|.|:
Worm   302 HKSSVMAVEFNKNGNWLLTGGRDHLVKMYDIRMMKE-MRTYR--AHKKEVISLAWHPIHEGLFVS 363

  Fly   442 GESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTL-WHPKLNQLFVSCGNGTIKCYYDEHRS 505
                  |..:.::.::.....:|:..:..::...:.:: ||| |..:..:..|.....::..:|
Worm   364 ------GGGDGSIVYWMVDGEKEIGLLEHAHDQAIWSMKWHP-LGHILATGSNDNNTKFWARNR- 420

  Fly   506 IRGAKLCVVKTHRKRQPMEMV----GVSQI-ITPHALPLFRQEKSRTSRKRMEKARMDPVKSQRP 565
                            |.:.|    |:|.. :..|.      :|.|..|....|..::..::.||
Worm   421 ----------------PGDTVEDIFGLSNTNMIGHL------DKEREPRMAPPKPSIETQETYRP 463

  Fly   566 D 566
            |
Worm   464 D 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	58/337 (17%)
		WD40	180..497	CDD:295369	57/315 (18%)
		WD40 repeat	185..227	CDD:293791	8/41 (20%)
		WD40 repeat	233..268	CDD:293791	6/34 (18%)
		WD40 repeat	273..329	CDD:293791	12/55 (22%)
		WD40 repeat	337..374	CDD:293791	8/38 (21%)
		WD40 repeat	382..419	CDD:293791	10/36 (28%)
		WD40 repeat	427..469	CDD:293791	5/42 (12%)
		WD40 repeat	475..497	CDD:293791	5/22 (23%)
pfs-2	NP_001380152.1	WD40	135..417	CDD:238121	57/319 (18%)
		WD40 repeat	136..173	CDD:293791	8/41 (20%)
		WD40 repeat	179..215	CDD:293791	6/48 (13%)
		WD40 repeat	220..256	CDD:293791	11/41 (27%)
		WD40 repeat	263..300	CDD:293791	8/41 (20%)
		WD40 repeat	306..342	CDD:293791	10/36 (28%)
		WD40 repeat	348..385	CDD:293791	5/42 (12%)
		WD40 repeat	392..416	CDD:293791	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910