DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and gpb-1

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001366714.1	Gene:	gpb-1 / 174803	WormBaseID:	WBGene00001679	Length:	340	Species:	Caenorhabditis elegans

Alignment Length:	292	Identity:	61/292 - (20%)
Similarity:	108/292 - (36%)	Gaps:	87/292 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 DDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDS 216
            |.|::::              .|.:.::  |..|:..|..|||:.:..|.:|.....:.....:.
Worm    83 DSYTTNK--------------VHAIPLR--SSWVMTCAYAPSGSFVACGGLDNICSIYSLKTREG 131

  Fly   217 SMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKG 281
            ::|..|:|   ..|         ||                     .|.||:   ::.|
Worm   132 NVRVSREL---PGH---------TG---------------------YLSCCR---FLDD------ 154

  Fly   282 HVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATL 346
                           .|.:|::.|.|..:|. :::.:|.... |...|.:.:.:.|.:|.   |.
Worm   155 ---------------NQIVTSSGDMTCALWD-IETGQQCTAF-TGHTGDVMSLSLSPDFR---TF 199

  Fly   347 IAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQF 411
            |:..| |.|.:.||.|......|.   ..|:  |:|.::.|...|...||.|:|.|.:|:|:|..
Worm   200 ISGAC-DASAKLWDIRDGMCKQTF---PGHE--SDINAVAFFPSGNAFATGSDDATCRLFDIRAD 258

  Fly   412 KQ-PLHTWTNLFSRYDTTDCCFSPDDRLLVTG 442
            :: .:::..|:..  ..|...||...|||..|
Worm   259 QELAMYSHDNIIC--GITSVAFSKSGRLLFAG 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	59/272 (22%)
		WD40	180..497	CDD:295369	58/264 (22%)
		WD40 repeat	185..227	CDD:293791	10/41 (24%)
		WD40 repeat	233..268	CDD:293791	4/34 (12%)
		WD40 repeat	273..329	CDD:293791	8/55 (15%)
		WD40 repeat	337..374	CDD:293791	11/36 (31%)
		WD40 repeat	382..419	CDD:293791	11/37 (30%)
		WD40 repeat	427..469	CDD:293791	7/16 (44%)
		WD40 repeat	475..497	CDD:293791
gpb-1	NP_001366714.1	WD40	48..340	CDD:238121	61/292 (21%)
		WD40 repeat	58..95	CDD:293791	3/25 (12%)
		WD40 repeat	101..141	CDD:293791	9/42 (21%)
		WD40 repeat	146..181	CDD:293791	10/60 (17%)
		WD40 repeat	188..223	CDD:293791	11/41 (27%)
		WD40 repeat	229..265	CDD:293791	11/35 (31%)
		WD40 repeat	273..309	CDD:293791	7/16 (44%)
		WD40 repeat	315..339	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910