DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and Wdr5

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_543124.1	Gene:	Wdr5 / 140858	MGIID:	2155884	Length:	334	Species:	Mus musculus

Alignment Length:	366	Identity:	74/366 - (20%)
Similarity:	152/366 - (41%)	Gaps:	64/366 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 VTTDKEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGAR 196
            :.|:::|...|:::.:.:.....:..:.:..:.:      |..:..:...::||.::...|:|..
Mouse     1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPN------YALKFTLAGHTKAVSSVKFSPNGEW 59

  Fly   197 LVSGSIDYDMCFWD-FAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDG 260
            |.|.|.|..:..|. :.|......|..:|      .|..:.:|...::::..|.:...|:.|...
Mouse    60 LASSSADKLIKIWGAYDGKFEKTISGHKL------GISDVAWSSDSNLLVSASDDKTLKIWDVSS 118

  Fly   261 FEKLECCKG-DQYISDMSRTKGHVAQLTSGCWHPFNREQ--FLTAALDGTLRIWQGLKSKEQLQV 322
            .:.|:..|| ..|:.               |.: ||.:.  .::.:.|.::|||. :|:.:.|:.
Mouse   119 GKCLKTLKGHSNYVF---------------CCN-FNPQSNLIVSGSFDESVRIWD-VKTGKCLKT 166

  Fly   323 IKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIV- 386
            :...:.     ..::.:||||.:||.:...||..:.|||.     :..|::......:...|.|
Mouse   167 LPAHSD-----PVSAVHFNRDGSLIVSSSYDGLCRIWDTA-----SGQCLKTLIDDDNPPVSFVK 221

  Fly   387 FSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTN-------LFSRYDTTDCCFSPDDRLLVTGES 444
            ||..|:.:...:.|.|:||||..:.| .|.|:|.       :|:.:..|.            |:.
Mouse   222 FSPNGKYILAATLDNTLKLWDYSKGK-CLKTYTGHKNEKYCIFANFSVTG------------GKW 273

  Fly   445 LPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLWHPKLN 485
            :..|..:..:|.::.::.|.||::......|:.|..||..|
Mouse   274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	71/326 (22%)
		WD40	180..497	CDD:295369	70/318 (22%)
		WD40 repeat	185..227	CDD:293791	11/42 (26%)
		WD40 repeat	233..268	CDD:293791	5/34 (15%)
		WD40 repeat	273..329	CDD:293791	9/57 (16%)
		WD40 repeat	337..374	CDD:293791	12/36 (33%)
		WD40 repeat	382..419	CDD:293791	14/37 (38%)
		WD40 repeat	427..469	CDD:293791	7/41 (17%)
		WD40 repeat	475..497	CDD:293791	5/11 (45%)
Wdr5	NP_543124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		3/29 (10%)
		WD40	37..331	CDD:238121	70/324 (22%)
		WD 1	43..82		10/38 (26%)
		WD40 repeat	48..85	CDD:293791	9/36 (25%)
		WD 2	85..126		7/46 (15%)
		WD40 repeat	91..127	CDD:293791	5/35 (14%)
		WD 3	128..168		10/56 (18%)
		WD40 repeat	132..168	CDD:293791	9/52 (17%)
		WD 4	169..208		12/48 (25%)
		WD40 repeat	175..210	CDD:293791	12/39 (31%)
		WD 5	212..253		14/41 (34%)
		WD40 repeat	217..253	CDD:293791	14/36 (39%)
		WD 6	256..296		7/51 (14%)
		WD40 repeat	261..298	CDD:293791	8/48 (17%)
		WD 7	299..333		5/16 (31%)
		WD40 repeat	304..330	CDD:293791	5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910