DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5543 and AgaP_AGAP001146

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_322015.3	Gene:	AgaP_AGAP001146 / 1282020	VectorBaseID:	AGAP001146	Length:	911	Species:	Anopheles gambiae

Alignment Length:	641	Identity:	109/641 - (17%)
Similarity:	213/641 - (33%)	Gaps:	220/641 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SGFGRKAAKVFDINEQIEKARVTRPGMDKKRE---ESKPKEDDQKDEEEEDVIGPLPPAVTTDKE 137
            :|.||....|.|.|.|:....    |.|::.|   ...|:|                     ..:
Mosquito   258 AGHGRTINLVADANGQVLGCH----GTDRQIELFLFCSPEE---------------------SMK 297

  Fly   138 KATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSG-- 200
            |.||...|   .|.:..|.:|.::.:.:|...|.....:......::...|.|..:..|:...
Mosquito   298 KLTKRMKK---LDTNKQSGEESANRQLALTDEIKRLTSIPTPEKVKSFDLLLGSRNELRICCTFV 359

  Fly   201 -------SIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQA----- 253
                   |:|.::      ..|:...:...||. :.||..:...:.:.|.:.:.||:|::
Mosquito   360 KNFVQLFSLDLNV------KKDAEPETLYALQK-QGHPSEARTVAFSSDSLAIASGSAESLKLWS 417

  Fly   254 -------KVLDRDGFEKLEC-CKGDQYISDMSRT-----------------KGHVAQLTS----- 288
                   :.:|..|:....| ..||:::....:|                 :.|..:|.|
Mosquito   418 RASQTVLRTVDTGGYVVSTCFVPGDRHVLVGLKTGQLLVVDVVPGEVIECIEAHEKELWSIVLTP 482

  Fly   289 ---GCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGG----------------LRTN 334
               ||         ::...|.|::.|       ..::|  .|.||                |...
Mosquito   483 DKHGC---------VSGGGDTTVKFW-------SFELI--AASGGQDAAKVLSLLHKNTLKLEET 529

  Fly   335 AASCNFNRDATLIAAGCVDGSIQTW--DTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATR 397
            ..|...:::...||...:|.:::.:  |:.|.:::..     .|:  ..:.::..||....:.|.
Mosquito   530 VLSVRISQNGKYIAVALLDTTVKIFFMDSLKFYLSLY-----GHK--LPVVTMDISYDSTLIITG 587

  Fly   398 SNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFS--PDDRLLVTGESLPKGQAEANLYFYSTK 460
            |.|.|:|:|.:                 |..||..|  ..|..:...:.:|    ..:::|...|
Mosquito   588 SADRTIKIWGM-----------------DFGDCHRSLLAHDNTVTAVQFIP----NTHMFFSCAK 631

  Fly   461 ----------SYEEVQRIP--VSNAHVVKTLWHPKLNQLFVSCGNG-TIKCYYDEHRSIRGAKLC 512
                      |::::..:|  :..||.:....:.|   ..||||:. |::.:
Mosquito   632 DGKLKQWDADSFQKIITLPGHLGEAHALAISPNGK---YVVSCGSDRTLRLF------------- 680

  Fly   513 VVKTHRKRQPMEMVGVSQIITPHALPLFRQEKSRTSRKRMEKARM-DPVKSQRPDLPITSGQGGR 576
                ||..:|:.:                |:.....|:.:|.|.: ...:|..|.||     |.:
Mosquito   681 ----HRTEEPLVL----------------QDVQEEEREELENATLATGEESTVPGLP-----GLK 720

  Fly   577 VASSGGTLSSYVIRNLGLSKRVDDDQDPREAILKYAKDAAENPYWIAP---AYKQT 629
            :.|.         :.:|..|..::..:..|...:|.::..:.|  :.|   ||..|
Mosquito   721 LPSK---------KTIGSEKGAENILECLEVSKQYEEEGGKGP--LPPLMFAYSAT 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	67/426 (16%)
		WD40	180..497	CDD:295369	66/396 (17%)
		WD40 repeat	185..227	CDD:293791	8/50 (16%)
		WD40 repeat	233..268	CDD:293791	7/47 (15%)
		WD40 repeat	273..329	CDD:293791	11/80 (14%)
		WD40 repeat	337..374	CDD:293791	6/38 (16%)
		WD40 repeat	382..419	CDD:293791	8/36 (22%)
		WD40 repeat	427..469	CDD:293791	8/53 (15%)
		WD40 repeat	475..497	CDD:293791	6/22 (27%)
AgaP_AGAP001146	XP_322015.3	WD40	3..440	CDD:225201	38/216 (18%)
		WD40 repeat	26..63	CDD:293791
		WD40	33..>221	CDD:295369
		WD40 repeat	69..105	CDD:293791
		WD40 repeat	110..146	CDD:293791
		WD40 repeat	153..188	CDD:293791
		WD40 repeat	195..236	CDD:293791
		WD40	<336..690	CDD:225201	69/442 (16%)
		WD40	387..680	CDD:238121	58/341 (17%)
		WD40 repeat	434..470	CDD:293791	4/35 (11%)
		WD40 repeat	475..523	CDD:293791	11/65 (17%)
		WD40 repeat	531..566	CDD:293791	6/34 (18%)
		WD40 repeat	573..608	CDD:293791	12/51 (24%)
		WD40 repeat	614..650	CDD:293791	4/39 (10%)
		WD40 repeat	657..680	CDD:293791	7/25 (28%)
		Utp12	768..869	CDD:281932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910