DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5543 and AgaP_AGAP001362

DIOPT Version :9

Sequence 1:	NP_611832.1	Gene:	CG5543 / 37768	FlyBaseID:	FBgn0034908	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_321783.5	Gene:	AgaP_AGAP001362 / 1281820	VectorBaseID:	AGAP001362	Length:	942	Species:	Anopheles gambiae

Alignment Length:	749	Identity:	148/749 - (19%)
Similarity:	249/749 - (33%)	Gaps:	284/749 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GGGFKKMDKEQMIRQIEDVAEDLESQHL-KEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKK 105
            |||....|             |.:.:.| |.||         .|..|.|..|.||...|......
Mosquito    57 GGGPMSQD-------------DFDGKRLRKSVM---------RKTVDYNASIIKALECRTWQRDH 99

  Fly   106 REESKPKEDDQKDEEEEDVIGP--LPP---------AVTTDKEK-ATKESSKDEDSDDDDYSSDE 158
            |        |::..:.|.:..|  |||         ||||...| ||.:
Mosquito   100 R--------DRRALQPESIYIPELLPPPSYMDNPSNAVTTRFVKTATNK---------------- 140

  Fly   159 DSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQ 223
                     .|.|             :..||..|.|.||::|:...:...|:  |:   |.:|..
Mosquito   141 ---------MRCP-------------IFTLAWTPEGRRLITGASSGEFTLWN--GL---MFNFET 178

  Fly   224 LQPCENHPIRSLQYS------VTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTK-- 280
            :....:..:|::.:|      |||               |..||.|       .:.|:|:..|
Mosquito   179 ILQAHDVSVRTMVWSHNDNWMVTG---------------DHGGFVK-------YWQSNMNNVKMF 221

  Fly   281 -GHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDA 344
             .|...:....:.| :..:|.:.:.|||:|:|..|:.:|:      |...|...:....:::...
Mosquito   222 QAHKDPIRGISFSP-SDAKFASCSDDGTVRVWDFLRCQEE------RVLRGHGADVKCVHWHPQK 279

  Fly   345 TLIAAGCVDGS--IQTWDTR-KMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLW 406
            .||.:|..|..  |:.||.: ...:.|.|    ||:  |.:..:.::..|..|.|.|.|..:||:
Mosquito   280 ALIVSGSKDNQQPIKLWDPKCGQALATLH----AHK--STVMDLKWNDNGNWLVTASRDHLLKLF 338

  Fly   407 DLRQFKQ------------------PLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEAN 453
            |||...:                  |:|  ..|||                       .|.::.:
Mosquito   339 DLRNLSEEVQVFRGHKKEASAVSWHPIH--EGLFS-----------------------SGGSDGS 378

  Fly   454 LYFYSTKSYEEVQRIPVSNAHVVKTL-WHP------------------------------KLNQL 487
            :.|::..:.:||..|.:::..:|.|| |||                              .||.|
Mosquito   379 ILFWNVGTDKEVGSIDMAHDSIVWTLAWHPLGHILCSGSNDHTVKFWTRNRPGDQMRDKYNLNTL 443

  Fly   488 FVSCGNGTIKCYYDEHRSIRGA----KLCVVKTHRKRQPMEMVGVSQIIT-----------PHAL 537
            ..|.. |..:|..:||..|.|.    |:.:|::...::...:.|:...:.           |::.
Mosquito   444 PASLA-GLDECELEEHIVIPGMGPEDKVDIVESIATKEAGPIPGLDLNLNSFNEKMREKKIPYSK 507

  Fly   538 PL---FRQEKSRTSRKRMEKARMDPVK---SQRPD--------------------LPITSGQGGR 576
            |:   |:.:.:.:|:.....:..|.:|   ||..|                    :|:..|....
Mosquito   508 PIPRNFQAQWNESSKLDDHSSTADEIKEVISQIVDRGPASPKKPLPTAISLYEHMIPVIPGSALE 572

  Fly   577 VASSGGT--LSSYVIRNLGL---------------SKRVDDDQDPREAILKYAKDA------AEN 618
            .|.|.||  |:.: |.|.|:               |...|::|.|:....:...|.      ...
Mosquito   573 QAISDGTEALNRF-IENGGIPQLRDIFPPIDEPEQSANGDEEQRPKPPAKRARLDVEPKFFYGPQ 636

  Fly   619 PYWIAPAYK-----------QTQPKAIFSEKLPA 641
            |:.:.|..:           :::....|..|||:
Mosquito   637 PFMMDPPEQSRDSVHSADDSRSKDDVTFDPKLPS 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5543	NP_611832.1	WD40	<172..519	CDD:225201	85/411 (21%)
		WD40	180..497	CDD:295369	78/377 (21%)
		WD40 repeat	185..227	CDD:293791	11/41 (27%)
		WD40 repeat	233..268	CDD:293791	9/40 (23%)
		WD40 repeat	273..329	CDD:293791	14/58 (24%)
		WD40 repeat	337..374	CDD:293791	9/39 (23%)
		WD40 repeat	382..419	CDD:293791	12/54 (22%)
		WD40 repeat	427..469	CDD:293791	4/41 (10%)
		WD40 repeat	475..497	CDD:293791	11/52 (21%)
AgaP_AGAP001362	XP_321783.5	WD40	142..425	CDD:238121	75/360 (21%)
		WD40	144..>428	CDD:225201	74/361 (20%)
		WD40 repeat	145..182	CDD:293791	11/41 (27%)
		WD40 repeat	188..223	CDD:293791	12/56 (21%)
		WD40 repeat	228..264	CDD:293791	10/42 (24%)
		WD40 repeat	271..308	CDD:293791	8/36 (22%)
		WD40 repeat	314..351	CDD:293791	10/36 (28%)
		WD40 repeat	358..394	CDD:293791	9/60 (15%)
		WD40 repeat	401..425	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910